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Cancer biology

Genome jail-break triggers lockdown

Nature volume 550, pages 340–341 (2017)Cite this article

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A pro-inflammatory response, the senescence-associated secretory phenotype, can affect development, ageing and cancer. It emerges that one trigger for this response is the presence of DNA in the cytoplasm. See Letter p.402

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Figure 1: A pro-inflammatory response promotes senescence.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and in the Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA

    Neil T. Umbreit & David Pellman

  2. Department of Cell Biology, Harvard Medical School, Boston

    Neil T. Umbreit & David Pellman

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  1. Neil T. Umbreit
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  2. David Pellman
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Correspondence to David Pellman.

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Umbreit, N., Pellman, D. Genome jail-break triggers lockdown. Nature 550, 340–341 (2017). https://doi.org/10.1038/nature24146

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