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Gene regulation

Expression feels two pulses

Single-cell analyses reveal that combinatorial changes in the intracellular locations of transcription factors can tune the expression of the factors' target genes in response to environmental stimuli. See Article p.54

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Figure 1: Interpreting transcription-factor pulses.


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  1. Corrigan, A. M. & Chubb, J. R. Curr. Biol. 24, 205–211 (2014).

    Article  CAS  Google Scholar 

  2. Lin, Y., Sohn, C. H., Dalal, C. K., Cai, L. & Elowitz, M. B. Nature 527, 54–58 (2015).

    Article  ADS  CAS  Google Scholar 

  3. Jacquet, M., Renault, G., Lallet, S., De Mey, J. & Goldbeter, A. J. Cell Biol. 161, 497–505 (2003).

    Article  CAS  Google Scholar 

  4. Hansen, A. S. & O'Shea, E. K. eLife 4, e06559 (2015).

    Article  Google Scholar 

  5. De Wever, V., Reiter, W., Ballarini, A., Ammerer, G. & Brocard, C. EMBO J. 24, 4115–4123 (2005).

    Article  CAS  Google Scholar 

  6. Drengstig, T., Ueda, H. R. & Ruoff, P. J. Phys. Chem. B 112, 16752–16758 (2008).

    Article  CAS  Google Scholar 

  7. Hsu, C. et al. Nature Commun. 3, 682 (2012).

    Article  Google Scholar 

  8. Gerstner, W. Neural Netw. 14, 599–610 (2001).

    Article  CAS  Google Scholar 

  9. Liang, H. et al. Nature Commun. 5, 4048 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Attila Becskei.

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Baudrimont, A., Becskei, A. Expression feels two pulses. Nature 527, 46–47 (2015).

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