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Molecular biology

Unequal opportunity during class switching

The DNA breakage-and-repair mechanism that generates antibodies of different classes has, in theory, a 50% chance of occurring correctly. But this recombination turns out to be heavily biased towards productive events. See Letter p.134

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Figure 1: Biased recombination.

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References

  1. Stavnezer, J. & Schrader, C. E. J. Immunol. 193, 5370–5378 (2014).

    CAS  Article  Google Scholar 

  2. Dong, J. et al. Nature 525, 134–139 (2015).

    ADS  CAS  Article  Google Scholar 

  3. Alt, F. W., Zhang, Y., Meng, F.-L., Guo, C. & Schwer, B. Cell 152, 417–429 (2013).

    CAS  Article  Google Scholar 

  4. Chiarle, R. et al. Cell 147, 107–119 (2011).

    CAS  Article  Google Scholar 

  5. Zarrin, A. A. et al. Science 315, 377–381 (2007).

    ADS  CAS  Article  Google Scholar 

  6. Ramiro, A. R. et al. Cell 118, 431–438 (2004).

    CAS  Article  Google Scholar 

  7. Bonaud, A. E. L. et al. Nature Commun. 6, 7613 (2015).

    ADS  Article  Google Scholar 

  8. Daniel, J. A. & Nussenzweig, A. Mol. Cell 50, 309–321 (2013).

    CAS  Article  Google Scholar 

  9. Zimmermann, M. & de Lange, T. Trends Cell Biol. 24, 108–117 (2014).

    CAS  Article  Google Scholar 

  10. Helmink, B. A. & Sleckman, B. P. Annu. Rev. Immunol. 30, 175–202 (2012).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Javier M. Di Noia.

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Di Noia, J. Unequal opportunity during class switching. Nature 525, 44–45 (2015). https://doi.org/10.1038/nature15209

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