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Systems biology

Network evolution hinges on history

The effects of mutations in proteins can depend on the occurrence of previous mutations. It emerges that such historical contingency is also important during the evolution of gene regulatory networks. See Letter p.361

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Figure 1: Not all evolutionary paths are possible.

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New, A., Lehner, B. Network evolution hinges on history. Nature 523, 297–298 (2015). https://doi.org/10.1038/nature14537

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