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DNA replication

Driving past four-stranded snags

Unusual DNA structures, such as G-quadruplexes, can stall DNA replication with drastic consequences for the cell. The Pif1 helicase family of enzymes has evolved to disentangle these structures efficiently. See Article p.458

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Figure 1: The problem at G-quadruplexes.

Notes

  1. *This article and the paper under discussion1 were published online on 8 May 2013.

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Correspondence to Sergei M. Mirkin.

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Mirkin, S. Driving past four-stranded snags. Nature 497, 449–450 (2013). https://doi.org/10.1038/nature12244

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