Abstract
The algorithm for estimating both the recombination fraction between a marker gene and a locus affecting a quantitative trait, and also the means and variances of the QTL genotypes, is extended to backcross and doubled haploid populations. The simulation experiments show that estimates of these parameters can be obtained with acceptable accuracy and results are compared with those obtained using F2 populations studied previously (Luo & Kearsey, 1989).
Similar content being viewed by others
Article PDF
References
Bhattacharya, G G. 1967. A simple method of resolution of a distribution into Gaussian components. Biometrics, 23, 115–135.
Botstein, D, White, R L, Skolnick, M, and Dawes, R W. 1980. Construction of a genetic linkage map in man using restriction fragment length polymorphism. Am J Hum Genet, 32, 314–331.
Cohen, A C. 1967. Estimation in mixtures of two normal distributions. Technometrics, 9, 15–28.
Day, N E. 1969. Estimating the components of a mixture of normal distributions. Biometrika, 56, 463–474.
Hasselblad, F. 1966. Mixture of normal distributions. Technometrics, 8, 231–250.
Hill, A P. 1975. Quantitative linkage: a statistical procedure for its detection and estimation. Ann Hum Genet London, 38, 439–449.
Jayakar, S D. 1970. On the detection and estimation of linkage between a locus influencing a quantitative character and a marker locus. Biometrics, 26, 451–464.
Lander, E S, and Botstein, D. 1989. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics, 121, 185–199.
Luo, Z W. 1989. Ph.D. Thesis. University of Birmingham.
Luo, Z W, and Kearsey, M J. 1989. Maximum likelihood estimation of linkage between a marker gene and a quantitative locus. Heredity, 63, 401–408.
Mather, K. 1936. Types of linkage data and their value. Ann Eugenics, 7, 251–264.
Mather, K. 1938. The Measurement of Linkage in Heredity. Methuen and Co. Ltd, London.
McMillan, I, and Robertson, A. 1974. The power of methods for the detection of major genes affecting quantitative characters. Heredity, 32, 349–356.
Mood, A M, Graybill, F A, and Boes, D C. 1974. Introduction to the Theory of Statistics. McGraw-Hill Book Company, New York.
Soller, M, and Brody, T. 1976. On the power of experimental designs for the detection of linkage between marker loci and quantitative loci in crosses between inbred lines. Theor Appl Genet, 47, 35–39.
Soller, M, and Genizi, A. 1978. The efficiency of experimental designs for the detection of linkage between a marker locus and a locus affecting a quantitative trait in segregating populations. Biometrics, 34, 47–55.
Tan, W Y, and Chang, W C. 1972. Some comparisons of the method of moments and the method of maximum likelihood in estimating parameters of a mixture of two normal densities. J Am Stat Assoc, 67, 702–708.
Thoday, J M. 1961. Location of polygenes. Nature, 191, 368–370.
Weller, J I. 1986. Maximum likelihood techniques for the mapping and analysis of quantitative trait loci with the aid of genetic markers. Biometrics, 42, 627–640.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Luo, Z., Kearsey, M. Maximum likelihood estimation of linkage between a marker gene and a quantitative trait locus. II. Application to backcross and doubled haploid populations. Heredity 66, 117–124 (1991). https://doi.org/10.1038/hdy.1991.14
Received:
Issue Date:
DOI: https://doi.org/10.1038/hdy.1991.14
Keywords
This article is cited by
-
Identification and validation of QTLs conferring resistance to sorghum downy mildew (Peronosclerospora sorghi) and Rajasthan downy mildew (P. heteropogoni) in maize
Theoretical and Applied Genetics (2005)
-
On the use of double haploids for detecting QTL in outbred populations
Heredity (2002)
-
Power of tests for quantitative trait loci detection using full-sib families in different schemes
Heredity (1996)
-
Genetic manipulation in plant breeding — prospects and limitations
Euphytica (1995)
-
Effect of genetic architecture on the power of human linkage studies to resolve the contribution of quantitative trait loci
Heredity (1994)