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Anti-ageing antibodies revive the immune system

Depleting an expanding pool of aberrant stem cells in aged mice using antibody therapy has been shown to rebalance blood cell production, diminish age-associated inflammation and strengthen acquired immune responses.
  1. Yasar Arfat T. Kasu

    1. Yasar Arfat T. Kasu is in the Division of Regenerative Medicine, Department of Medicine, Stem Cell Discovery Center, Sanford Stem Cell Institute, Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.

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  2. Robert A. J. Signer

    1. Robert A. J. Signer is in the Division of Regenerative Medicine, Department of Medicine, Stem Cell Discovery Center, Sanford Stem Cell Institute, Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.

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Ageing is a major risk factor for most chronic diseases. As the global population continues to age, interventions that mitigate effects of ageing could profoundly affect wellness, the economy and society at large by extending human healthspan. Many age-associated diseases and declines in tissue function are associated with alterations in the fitness and function of stem cells, including those in the blood1. Writing in Nature, Ross et al.2 report that an antibody-based therapy that depletes aberrant stem cells can rejuvenate the immune system in aged mice by rebalancing the production of blood cells.

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Nature 628, 43-45 (2024)

doi: https://doi.org/10.1038/d41586-024-00680-x

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Competing Interests

The authors declare no competing interests.

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