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Interactions between immune cells recorded

Direct interactions between cells in tissue are incompletely understood because the advanced technologies required to examine them are still in their infancy. A new method can decipher cell–cell interactions on a large scale.
  1. Michael A. Wheeler

    1. Michael A. Wheeler is at the Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, and at The Gene Lay Institute of Immunology and Inflammation, Boston, Massachusetts 02115, USA.

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In living tissues, millions of cells communicate with each other within fractions of a second. How are these dynamic intercellular interactions orchestrated? Writing in Nature, Nakandakari-Higa et al.1 present a method called universal LIPSTIC (uLIPSTIC) that offers a way to address the challenge of investigating transient interactions between cells of the immune system that come into close physical proximity. This technique can also be adapted to study interactions between other cell types.

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Nature 627, 277-279 (2024)

doi: https://doi.org/10.1038/d41586-024-00426-9

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Competing Interests

The author declares no competing interests.

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