Time of day shapes the success of a cancer treatment

Gabriel, Christian H.; Kramer, Achim

doi:10.1038/d41586-023-00068-3

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17 January 2023

Time of day shapes the success of a cancer treatment

Daily rhythms affect many aspects of mammalian biology. A discovery in mice that the activity of a key type of immune cell is shaped by such rhythms might have implications for clinical efforts to tackle cancer.

Christian H. Gabriel⁰ &
Achim Kramer¹

Christian H. Gabriel
1. Christian H. Gabriel is at Charité – Universitätsmedizin Berlin, Institute of Medical Immunology, 10117 Berlin, Germany.
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Achim Kramer
1. Achim Kramer is at Charité – Universitätsmedizin Berlin, Institute of Medical Immunology, 10117 Berlin, Germany.
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When is the best time of day to fight cancer? Cancer cells can arise in our bodies at any time, but, fortunately, they are almost always recognized and eliminated by the immune system¹. Therefore, engaging these defences is an important strategy in many promising new cancer immunotherapy approaches. Writing in Nature, Wang et al.² show that the ability of immune cells to recognize cancer cells and promote their removal is dependent on the body’s internal clock, a finding that might be exploited to improve the effectiveness of cancer treatments.

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Nature 614, 41-42 (2023)

doi: https://doi.org/10.1038/d41586-023-00068-3

References

Shankaran, V. et al. Nature 410, 1107–1111 (2001).
Article Google Scholar
Wang, C. et al. Nature 614, 136–143 (2022).
Article Google Scholar
Robles, M. S., Cox, J. & Mann, M. PLoS Genet. 10, e1004047 (2014).
Article PubMed Google Scholar
Pick, R., He, W., Chen, C.-S. & Scheiermann, C. Trends Immunol. 40, 524–537 (2019).
Article PubMed Google Scholar
Qian, D. C. et al. Lancet Oncol. 22, 1777–1786 (2021).
Article PubMed Google Scholar
Beatty, G. L. & Gladney, W. L. Clin. Cancer Res. 21, 687–692 (2015).
Article PubMed Google Scholar
Long, J. E. et al. Vaccine 34, 2679–2685 (2016).
Article PubMed Google Scholar
Kramer, A. et al. PLoS Biol. 20, e3001567 (2022).
Article PubMed Google Scholar