Killing the messenger to evade bacterial defences

Jenal, Urs

doi:10.1038/d41586-022-01127-x

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29 April 2022

Killing the messenger to evade bacterial defences

Many mysteries remain about how antiviral responses shape the ability of viruses to infect bacteria. The finding that viruses interfere with signalling mediated by molecules called second messengers sheds light on bacterial defences.

Urs Jenal ⁰

Urs Jenal
1. Urs Jenal is at the Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
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In ancient times, the delivery of an unwelcome message by an envoy to those in high office posed a risk of retribution for the envoy. In Sophocles’ play Antigone, a guard says, “No man delights in the bearer of bad news.” Moreover, neutralizing information carriers is an effective manoeuvre for undermining an enemy’s lines of communication during war. It turns out that viruses that infect bacteria (bacteriophages, or phages) optimize predation of their microbial hosts by targeting messengers needed for defence systems. Writing in Nature, Hobbs et al.¹ report that phages use nuclease enzymes to degrade microbial molecules called nucleotide second messengers, and thereby subvert antiviral responses.

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Nature 605, 431-432 (2022)

doi: https://doi.org/10.1038/d41586-022-01127-x

References

Hobbs, S. J. et al. Nature 605, 522–526 (2022).
Article Google Scholar
Sutherland, E. W. & Robison, G. A. Pharmacol. Rev. 18, 145–161 (1966).
PubMed Google Scholar
Ross, P. et al. Nature 325, 279–281 (1987).
PubMed Article Google Scholar
Witte, G., Hartung, S., Büttner, K. & Hopfner, K.-P. Mol. Cell 30, 167–178 (2008).
PubMed Article Google Scholar
Davies, B. W., Bogard, R. W., Young, T. S. & Mekalanos, J. J. Cell 149, 358–370 (2012).
PubMed Article Google Scholar
Cohen, D. et al. Nature 574, 691–695 (2019).
PubMed Article Google Scholar
Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Science 339, 786–791 (2013).
PubMed Article Google Scholar
Ablasser, A. et al. Nature 498, 380–384 (2013).
PubMed Article Google Scholar
Wu, J. et al. Science 339, 826–830 (2013).
PubMed Article Google Scholar
Burdette, D. L. et al. Nature 478, 515–518 (2011).
PubMed Article Google Scholar
Hopfner, K.-P. & Hornung, V. Nature Rev. Mol. Cell Biol. 21, 501–521 (2020).
PubMed Article Google Scholar
Wein, T. & Sorek, R. Nature Rev. Immunol. https://doi.org/10.1038/s41577-022-00705-4 (2022).
Article Google Scholar
Whiteley, A. T. et al. Nature 567, 194–199 (2019).
PubMed Article Google Scholar
Ye, Q. et al. Mol. Cell 77, 709–722 (2020).
PubMed Article Google Scholar
Govande, A. A., Duncan-Lowey, B., Eaglesham, J. B., Whiteley, A. T. & Kranzusch, P. J. Cell Rep. 35, 109206 (2021).
PubMed Article Google Scholar
Morehouse, B. R. et al. Nature 586, 429–433 (2020).
PubMed Article Google Scholar
Tal, N. et al. Cell 184, 5728–5739 (2021).
PubMed Article Google Scholar
Jenal, U., Reinders, A. & Lori, C. Nature Rev. Microbiol. 15, 271–284 (2017).
PubMed Article Google Scholar
Eaglesham, J. B., Pan, Y., Kupper, T. S. & Kranzusch, P. J. Nature 566, 259–263 (2019).
PubMed Article Google Scholar
Athukoralage, J. S. et al. Nature 577, 572–575 (2020).
PubMed Article Google Scholar

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The author declares no competing interests.

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[1] Hobbs, S. J. et al. Nature 605, 522–526 (2022).
Article Google Scholar

[2] Sutherland, E. W. & Robison, G. A. Pharmacol. Rev. 18, 145–161 (1966).
PubMed Google Scholar

[3] Ross, P. et al. Nature 325, 279–281 (1987).
PubMed Article Google Scholar

[4] Witte, G., Hartung, S., Büttner, K. & Hopfner, K.-P. Mol. Cell 30, 167–178 (2008).
PubMed Article Google Scholar

[5] Davies, B. W., Bogard, R. W., Young, T. S. & Mekalanos, J. J. Cell 149, 358–370 (2012).
PubMed Article Google Scholar

[6] Cohen, D. et al. Nature 574, 691–695 (2019).
PubMed Article Google Scholar

[7] Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Science 339, 786–791 (2013).
PubMed Article Google Scholar

[8] Ablasser, A. et al. Nature 498, 380–384 (2013).
PubMed Article Google Scholar

[9] Wu, J. et al. Science 339, 826–830 (2013).
PubMed Article Google Scholar

[10] Burdette, D. L. et al. Nature 478, 515–518 (2011).
PubMed Article Google Scholar

[11] Hopfner, K.-P. & Hornung, V. Nature Rev. Mol. Cell Biol. 21, 501–521 (2020).
PubMed Article Google Scholar

[12] Wein, T. & Sorek, R. Nature Rev. Immunol. https://doi.org/10.1038/s41577-022-00705-4 (2022).
Article Google Scholar

[13] Whiteley, A. T. et al. Nature 567, 194–199 (2019).
PubMed Article Google Scholar

[14] Ye, Q. et al. Mol. Cell 77, 709–722 (2020).
PubMed Article Google Scholar

[15] Govande, A. A., Duncan-Lowey, B., Eaglesham, J. B., Whiteley, A. T. & Kranzusch, P. J. Cell Rep. 35, 109206 (2021).
PubMed Article Google Scholar

[16] Morehouse, B. R. et al. Nature 586, 429–433 (2020).
PubMed Article Google Scholar

[17] Tal, N. et al. Cell 184, 5728–5739 (2021).
PubMed Article Google Scholar

[18] Jenal, U., Reinders, A. & Lori, C. Nature Rev. Microbiol. 15, 271–284 (2017).
PubMed Article Google Scholar

[19] Eaglesham, J. B., Pan, Y., Kupper, T. S. & Kranzusch, P. J. Nature 566, 259–263 (2019).
PubMed Article Google Scholar

[20] Athukoralage, J. S. et al. Nature 577, 572–575 (2020).
PubMed Article Google Scholar

Killing the messenger to evade bacterial defences

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