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CRISPR gene editing produces unwanted DNA deletions

DNA-cutting enzyme used for genetic modification can create large deletions and shuffle genes.
  1. Heidi Ledford
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Researchers have embraced CRISPR gene-editing as a method for altering genomes, but some are cautioning that unwanted DNA changes may slip by undetected.

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doi: https://doi.org/10.1038/d41586-018-05736-3

References

  1. Kosicki, M., Tomberg, K. & Bradley, A. Nature Biotechnol. http://doi.org/10.1038/nbt.4192 (2018).

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  2. Shin, H. Y. et al. Nature Commun. 8, 15464 (2017)

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