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Antibodies achieve leptin balancing act

  1. M. Teresa Villanueva
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Leptin is an adipose tissue hormone that regulates energy and metabolic balance by activating the leptin receptor (LEPR). An imbalance in leptin or LEPR signalling — whether through hyperleptinemia or hypoleptinemia — causes obesity, glucose intolerance and insulin resistance. Two articles in Science Translational Medicine have now described the development of two monoclonal antibodies (mAbs) with opposing functions but a common result: rebalancing leptin signalling to prevent weight gain, restoring glucose tolerance, and preserving adipose tissue and liver function.

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Nature Reviews Drug Discovery 23, 21 (2024)

doi: https://doi.org/10.1038/d41573-023-00203-9

References

  1. Altarejos, J. Y. et al. Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency. Sci. Transl Med. 15, eadd4897 (2023).

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  2. Zhao, S. et al. Hyperleptinemia contributes to antipsychotic drug–associated obesity and metabolic disorders. Sci. Transl Med. 15, eade8460 (2023).

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