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Long non-coding RNA MEG3 promotes the proliferation of glioma cells through targeting Wnt/β-catenin signal pathway

Cancer Gene Therapy volume 24, pages 381–385 (2017)Cite this article

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Abstract

Glioma has been identified as one of the most aggressive primary tumors. Long non-coding RNAs (lncRNAs), with length larger than 200 bp, have drawn increasing attention to their abnormal expression and regulation function in carcinogenesis. However, the role of lncRNAs in glioma remains largely unknown. Maternally expressed gene 3 (MEG3), also known as gene-trap locus 2 (GTL2), is an imprinted gene, and is encoded by the MEG3 transcript of the DLK1/MEG3 locus on human chromosome, or Meg3 on mouse chromosome. In this study, we found that lncRNA MEG3 was significantly downregulated in malignant glioma tissues and cell lines. The employment of the loss-of and gain-of functions assays presented that MEG3 suppressed glioma cells proliferation and induced cell-cycle arrest. Furthermore, our findings showed that highly expressed MEG3 could weaken Wnt/β-catenin signaling in glioma. Collectively, our findings revealed that downregulated lncRNA MEG3 could promote glioma cell proliferation through targeting Wnt/β-catenin signaling, which mainly influenced cell cycle.

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Acknowledgements

We thank the laboratory members.

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Authors and Affiliations

  1. Department of Neurosurgery, Hunan Provincial People's Hospital, Changsha, 410005, Hunan Province, China,

    X Gong & M Huang

  2. The First Affiliated Hospital of Hunan Normal University, Changsha, 410005, Hunan Province, China,

    X Gong & M Huang

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  1. X Gong
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Correspondence to M Huang.

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Gong, X., Huang, M. Long non-coding RNA MEG3 promotes the proliferation of glioma cells through targeting Wnt/β-catenin signal pathway. Cancer Gene Ther 24, 381–385 (2017). https://doi.org/10.1038/cgt.2017.32

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