Abstract
p53 codon 72 polymorphism was analysed in UK women with human papillomavirus (HPV)-associated vulval intraepithelial neoplasia and vulval squamous cell carcinoma. Arginine homozygotes were significantly less common in either group compared with controls. We conclude that the arginine polymorphism may confer protection against the development of HPV-associated vulval neoplasia. © 2000 Cancer Research Campaign
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References
Birgander R, Sjalander A, Rannug A, Alexandrie AK, Sundberg MI, Seidegard J, Tornling G, Beckman G and Beckman L (1995) P53 polymorphisms and haplotypes in lung cancer. Carcinogenesis 16: 2233–2236
Birgander R, Sjalander A, Zhou Z, Fan C, Beckman L and Beckman G (1996) p53 polymorphisms and haplotypes in nasopharyngeal cancer. Hum Hered 46: 49–54
Bosch FX, Manos MM, Munoz N, Sherman M, Jansen AM, Peto J, Schiffman MH, Moreno V, Kurman R and Shah KV (1995) Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) study group. J Natl Cancer Inst 87: 796–802
Hamel N, Black MJ, Ghadirian P and Foulkes WD (2000) No association between p53 codon 72 polymorphism and risk of squamous cell carcinoma of the head and neck. Br J Cancer 82: 757–759
Hayes VM, Hofstra RMW, Buys CHCM, Hollema H and van de Zee AGJ (1998) Homozygous arginine-72 in wild type p53 and risk of cervical cancer. Lancet 352: 1756
Helland A, Langerod A, Johnsen H, Olsen A, Skovlund E and Borresen-Dale A-L (1998) p53 polymorphism and risk of cervical cancer. Nature 396: 830–831
Hildesheim A, Schiffman M, Brinton LA, Fraumeni JF Jr, Herrero R, Bratti MC, Schwartz P, Mortel R, Barnes W, Greenberg M, McGowan L, Scott DR, Martin M, Herrera JE and Carrington M (1998) p53 polymorphism and risk of cervical cancer. Nature 396: 531–532
Hording U, Kringshome B, Andreasson B, Visfeldt J, Daugaard S and Bock JE (1993) Human papillomavirus in vulvar squamous-cell carcinoma and in normal vulvar tissue: a search for a possible impact of HPV on vulvar cancer prognosis. Int J Cancer 55: 394–396
Joseffson AM, Magnusson PKE, Ylitalo N, Quarforth-Tubin P, Ponten J, Adami HO and Gyllensten UB (1998) p53 polymorphism and risk of cervical cancer. Nature 396: 531
Kagie MJ, Kenter GG, Zomerdijk-Nooijen Y, Hermans J, Schuuring E, Timmers PJ, Trimbos JB and Fleuren GJ (1997) Human papillomavirus infection in squamous cell carcinoma of the vulva, in various synchronous epithelial changes and in normal vulvar skin. Gynecol Oncol 67: 178–183
Kohlberger P, Kainz C, Breitenecker G, Gitsch G, Sliutz G, Kolbl H, Tschachler E and Reinthaller A (1998) Absence of p53 protein overexpression in precancerous lesions of the vulva. Cancer 82: 322–327
Lanham S, Campbell I, Watt P and Gornall R (1998) p53 polymorphism and risk of cervical cancer. Lancet 352: 1631
Lee YY, Wilnczynski SP, Chumakov A, Chih D and Koeffler HP (1994) Carcinoma of the vulva: HPV and p53 mutations. Oncogene 9: 1655–1659
Marshall SE, Bordea C, Wojnarowska F, Morris PJ and Welsh KI (2000) p53 codon 72 polymorphism and susceptibility to skin cancer after renal transplantation. Transplantation 69: 994–996
Minaguchi T, Kanamori Y, Matsushima M, Yoshikawa H, Takateni Y and Nakamura Y (1998) No evidence of correlation between polymorphism at codon 72 of p53 and risk of cervical cancer in Japanese patients with human papillomavirus 16/18 infection. Cancer Research 58: 4585–4586
Ngan HY, Liu VW and Liu SS 1999a) Risk of cervical cancer is not increased in Chinese carrying homozygous arginine at codon 72 of p53. Br J Cancer 80: 1828–1829
Ngan HY, Cheung AN, Liu SS, Yip PS and Tsao SW 1999b) Abnormal expression or mutation of TP53 and HPV in vulvar cancer. Eur J Cancer 35: 481–484
Rosenthal AN, Ryan A, Al-Jehani RM and Jacobs IJ (1998) p53 codon 72 polymorphism and risk of cervical cancer in UK. Lancet 352: 871–872
Sonada Y, Saigo PE and Boyd J (1999) p53 and genetic susceptibility to cervical cancer. J Natl Cancer Inst 91: 557
Storey A, Thomas M, Kalita A, Harwood C, Gardiol D, Mantovani F, Breuer J, Leigh IM, Matlewski G and Banks L (1998) Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature 393: 229–234
Walboomers JMM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snidjers PJ, Peto J, Meijer CJ and Munoz N (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189: 12–19
Wang NM, Tsai CH, Yah KT, Chen SJ and Chang JG (1999) p53 codon 72Arg polymorphism is not a risk factor for cervical cancer in the Chinese. Int J Mol Med 4: 249–252
Zehbe I, Voglino G, Wilander E, Genta F and Tommasino M (1999) Codon 72 polymorphism of p53 and its association with cervical cancer. Lancet 354: 218–219
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Rosenthal, A., Ryan, A., Hopster, D. et al. p53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia. Br J Cancer 83, 1287–1290 (2000). https://doi.org/10.1054/bjoc.2000.1419
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DOI: https://doi.org/10.1054/bjoc.2000.1419
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