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Cell signalling

Nutrient sensing lost in cancer

Cells can sense and respond to fluctuations in nutrient availability. Mutations that disrupt such lines of nutrient communication with the cellular growth machinery seem to contribute to the uncontrolled growth of cancer cells.

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Figure 1: Nutrient sensing and mTORC1.

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Correspondence to Brendan D. Manning.

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Menon, S., Manning, B. Nutrient sensing lost in cancer. Nature 498, 444–445 (2013). https://doi.org/10.1038/498444a

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