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Cancer biology

The director's cut

A Correction to this article was published on 16 May 2012

A genome-wide characterization of active translation of messenger RNA following inhibition of mTOR will transform our view of this signalling protein's regulatory role in cancer. See Article p.55 & Letter p.109

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Figure 1: The translational landscape of mTOR.

References

  1. Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. & Weissman, J. S. Science 324, 218–213 (2009).

    Article  CAS  ADS  Google Scholar 

  2. Hsieh, A. C. et al. Nature 485, 55–61 (2012).

    Article  CAS  ADS  Google Scholar 

  3. Thoreen, C. C. et al. Nature 485, 109–113 (2012).

    Article  CAS  ADS  Google Scholar 

  4. Dowling, R. J. et al. Science 328, 1172–1176 (2010).

    Article  CAS  ADS  Google Scholar 

  5. Yip, C. K., Murata, K., Walz, T., Sabatini, D. M. & Kang, S. A. Mol. Cell 38, 768–774 (2010).

    Article  CAS  Google Scholar 

  6. Thomas, H. E. et al. Sci. Transl. Med. http://dx.doi.org/10.1126/scitranslmed.3003923 (2012).

  7. Larsson, O. et al. Proc. Natl Acad. Sci. USA (in the press).

  8. Levy, S., Avni, D., Hariharan, N., Perry, R. P. & Meyuhas, O. Proc. Natl Acad. Sci. USA 88, 3319–3323 (1991).

    Article  CAS  ADS  Google Scholar 

  9. Jeffries, H. B. et al. EMBO J. 16, 3693–3704 (1997).

    Article  Google Scholar 

  10. Shama, S. et al. Gene Exp. 4, 241–252 (1995).

    CAS  Google Scholar 

  11. Ivanov, P., Kedersha, N. & Anderson, P. Genes Dev. 25, 2119–2124 (2011).

    Article  CAS  Google Scholar 

  12. MacNicol, M. C. & MacNicol, A. M. Mol. Reprod. Dev. 77, 662–669 (2010).

    Article  CAS  Google Scholar 

  13. Bader, A. G. & Vogt, P. K. Oncogene 27, 1179–1182 (2008).

    Article  CAS  Google Scholar 

Download references

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Correspondence to George Thomas.

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Gentilella, A., Thomas, G. The director's cut. Nature 485, 50–51 (2012). https://doi.org/10.1038/485050a

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