Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cancer biology

The director's cut

Nature volume 485, pages 50–51 (2012)Cite this article

Subjects

A Correction to this article was published on 16 May 2012

A genome-wide characterization of active translation of messenger RNA following inhibition of mTOR will transform our view of this signalling protein's regulatory role in cancer. See Article p.55 & Letter p.109

Many cellular responses to external stimuli are comparable to the integrated performances of musicians in an orchestra, as directed by the conductor. By elucidating cellular signalling pathways, scientists can identify the individual components underlying disease, and attempt pharmacological mitigation. These ambitious goals require groundbreaking approaches. One such tool is ribosome profiling — a global approach to assess active translation of cellular messenger RNA that provides an unprecedented picture of the regulation of protein synthesis1. In this issue, Hsieh et al.2 (page 55) and Thoreen et al.3 (page 109) use this method to analyse the 'translational landscape' controlled by a kinase protein named mTOR, a key regulator of protein synthesis.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The translational landscape of mTOR.

References

  1. Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. & Weissman, J. S. Science 324, 218–213 (2009).

    Article  CAS  ADS  Google Scholar 

  2. Hsieh, A. C. et al. Nature 485, 55–61 (2012).

    Article  CAS  ADS  Google Scholar 

  3. Thoreen, C. C. et al. Nature 485, 109–113 (2012).

    Article  CAS  ADS  Google Scholar 

  4. Dowling, R. J. et al. Science 328, 1172–1176 (2010).

    Article  CAS  ADS  Google Scholar 

  5. Yip, C. K., Murata, K., Walz, T., Sabatini, D. M. & Kang, S. A. Mol. Cell 38, 768–774 (2010).

    Article  CAS  Google Scholar 

  6. Thomas, H. E. et al. Sci. Transl. Med. http://dx.doi.org/10.1126/scitranslmed.3003923 (2012).

  7. Larsson, O. et al. Proc. Natl Acad. Sci. USA (in the press).

  8. Levy, S., Avni, D., Hariharan, N., Perry, R. P. & Meyuhas, O. Proc. Natl Acad. Sci. USA 88, 3319–3323 (1991).

    Article  CAS  ADS  Google Scholar 

  9. Jeffries, H. B. et al. EMBO J. 16, 3693–3704 (1997).

    Article  Google Scholar 

  10. Shama, S. et al. Gene Exp. 4, 241–252 (1995).

    CAS  Google Scholar 

  11. Ivanov, P., Kedersha, N. & Anderson, P. Genes Dev. 25, 2119–2124 (2011).

    Article  CAS  Google Scholar 

  12. MacNicol, M. C. & MacNicol, A. M. Mol. Reprod. Dev. 77, 662–669 (2010).

    Article  CAS  Google Scholar 

  13. Bader, A. G. & Vogt, P. K. Oncogene 27, 1179–1182 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Antonio Gentilella and George Thomas are at the Catalan Institute of Oncology, ICO, Bellvitge Biomedical Research Institute, IDIBELL, 08908 Barcelona, Spain.,

    Antonio Gentilella & George Thomas

  2. George Thomas is also in the Department of Internal Medicine, Metabolic Diseases Institute, University of Cincinnati, USA.,

    George Thomas

Authors
  1. Antonio Gentilella
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. George Thomas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to George Thomas.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gentilella, A., Thomas, G. The director's cut. Nature 485, 50–51 (2012). https://doi.org/10.1038/485050a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/485050a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer