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Stem cells

iPS cells under attack

Induced pluripotent stem cells offer promise for patient-specific regenerative therapy. But a study now cautions that, even when immunologically matched, these cells can be rejected after transplantation. See Letter p.212

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Figure 1: Immunogenicity of induced pluripotent stem cells.


  1. 1

    Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    CAS  Article  Google Scholar 

  2. 2

    Stadtfeld, M. & Hochedlinger, K. Genes Dev. 24, 2239–2263 (2010).

    CAS  Article  Google Scholar 

  3. 3

    Wu, S. M. & Hochedlinger, K. Nature Cell Biol. 13, 497–505 (2011).

    CAS  Article  Google Scholar 

  4. 4

    Zhao, T., Zhang, Z.-N., Rong, Z. & Xu, Y. Nature 474, 212–215 (2011).

    CAS  Article  Google Scholar 

  5. 5

    Kim, K. et al. Nature 467, 285–290 (2010).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Polo, J. M. et al. Nature Biotechnol. 28, 848–855 (2010).

    CAS  Article  Google Scholar 

  7. 7

    Hanna, J. et al. Science 318, 1920–1923 (2007).

    ADS  CAS  Article  Google Scholar 

Download references

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Correspondence to Konrad Hochedlinger.

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Competing interests

K.H. is an adviser to iPerian, Inc.

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Apostolou, E., Hochedlinger, K. iPS cells under attack. Nature 474, 165–166 (2011).

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