Progress | Published:

The enigma of the natural killer cell

Nature volume 378, pages 245248 (16 November 1995) | Download Citation

Subjects

Abstract

Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants. Whereas human NK cell class I receptors consist of immunoglobulin domains, their mouse counterparts resemble C-type lee-tins. This difference may reflect the receptors' diverse and rapidly evolving class I ligands.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    in Fundamental Immunology (ed. Paul, W. E.) 75–109 (Raven, New York. 1993).

  2. 2.

    Adv. Immun. 47, 187–386 (1989).

  3. 3.

    & A. Rev. Immun. 7, 601–624 (1989).

  4. 4.

    Nat. Immun. Cell Growth Reg. 5, 169–199 (1986).

  5. 5.

    , & A. Rev. Immun. 10, 189–213 (1992).

  6. 6.

    & Science 214, 24–30 (1981).

  7. 7.

    & A. Rev. Cell Biol. 9, 163–206 (1993).

  8. 8.

    , & A. Rev. Immun. 4, 651–680 (1986).

  9. 9.

    , , & J. exp. Med. 178, 1857–1866 (1993).

  10. 10.

    et al. J. exp. Med. 180, 569–576 (1994).

  11. 11.

    et al. J. Immun. 137, 2735–2739 (1986).

  12. 12.

    , , & Nature 319, 675–678 (1986).

  13. 13.

    & Nature 334, 395–401 (1988).

  14. 14.

    & A. Rev. Biochem. 59, 253–288 (1990).

  15. 15.

    & A. Rev. Immun. 2, 359–394 (1984).

  16. 16.

    J. exp. Med. 180, 417–421 (1994).

  17. 17.

    , , , & Science 253, 199–202 (1991).

  18. 18.

    et al. Nature 349, 329–331 (1991).

  19. 19.

    & Eur. J. Immun. 19, 447–451 (1989).

  20. 20.

    et al. J. Immun. 143, 3853–3857 (1989).

  21. 21.

    et al. Proc. natn. Acad. Sci. U.S.A. 88, 5989–5992 (1991).

  22. 22.

    et al. J. exp. Med. 172, 47–52 (1990).

  23. 23.

    et al. J. exp. Med. 178, 1321–1336 (1993).

  24. 24.

    et al. Proc. natn. Acad. Sci. U.S.A. 89, 7983–7985 (1992).

  25. 25.

    et al. Science 260, 1121–1124 (1993).

  26. 26.

    , , & J. Immun. 137, 3671–3674 (1986).

  27. 27.

    et al. J. exp. Med. 181, 1133–1144 (1995).

  28. 28.

    et al. J. exp. Med. 180, 1235–1242 (1994).

  29. 29.

    et al. J. exp. Med. 175, 709–718 (1992).

  30. 30.

    , & Nature 358, 66–70 (1992).

  31. 31.

    et al. J. exp. Med. 180, 641–651 (1994).

  32. 32.

    , & in Natural Immunity to Normal Hemopoietic Cells (ed. Rolstad, B.) 99–149 (CRC, Boca Raton, FL, 1994).

  33. 33.

    et al. J. Immun. 153, 5482–5490 (1994).

  34. 34.

    , & Nature 372, 379–383 (1994).

  35. 35.

    et al. Nature 368, 711–718 (1994).

  36. 36.

    et al. J. exp. Med. 180, 687–692 (1994).

  37. 37.

    J. exp. Med. 179, 1011–1015 (1994).

  38. 38.

    & A. Rev. Immun. 11, 613–635 (1993).

  39. 39.

    , , & J. Immun. 145, 2353–2358 (1990).

  40. 40.

    et al. J. Immun. 147, 1417–1423 (1991).

  41. 41.

    , & J. Immun. 153, 1068–1079 (1994).

  42. 42.

    , , & J. exp. Med. 170, 191–202 (1989).

  43. 43.

    , , & J. exp. Med. 180, 2287–2295 (1994).

  44. 44.

    et al. J. Immun. 143, 1379–1386 (1989).

  45. 45.

    , & Glycobiology 3, 9–14 (1993).

  46. 46.

    Prog. nucleic Acid Res. molec. Biol. 45, 207–232 (1993).

  47. 47.

    et al. Immunity 1, 785–792 (1995).

  48. 48.

    et al. J. Immun. 147, 3229–3236 (1991).

  49. 49.

    et al. J. Immun. 149, 581–589 (1992).

  50. 50.

    et al. Science 249, 1298–1300 (1990).

  51. 51.

    et al. J. Immun. 147, 3244–3250 (1991).

  52. 52.

    et al. J. biol. Chem. 269, 16945–16952 (1994).

  53. 53.

    et al. Nature 372, 150–157 (1994).

  54. 54.

    , , & J. Immun. 149, 1957–1963 (1992).

  55. 55.

    et al. J. Immun. 149, 1631–1635 (1992).

  56. 56.

    et al. J. Immun. 152, 1228–1236 (1994).

  57. 57.

    et al. Immunogenetics 37, 455–460 (1993).

  58. 58.

    , & J. Immun. 153, 2417–2428 (1994).

  59. 59.

    et al. J. exp. Med. 178, 537–547 (1993).

  60. 60.

    et al. Eur. Immun. (in the press).

  61. 61.

    , , & J. exp. Med. 173, 1017–1020 (1991).

  62. 62.

    et al. Immunogenetics 39, 218 (1994).

  63. 63.

    et al. J. exp. Med. 172, 1589–1598 (1990).

  64. 64.

    et al. J. exp. Med. 171, 695–714 (1990).

  65. 65.

    et al. J. exp. Med. 180, 537–543 (1994).

  66. 66.

    et al. J. Immun. 152, 1662–1673 (1994).

  67. 67.

    et al. J. exp. Med. 178, 597–604 (1993).

  68. 68.

    et al. Immunity 2, 439–449 (1995).

  69. 69.

    & Science 268, 405–408 (1995).

  70. 70.

    et al. J. Immun. 155, 2306–2310 (1995).

  71. 71.

    et al. J. Immun. 154, 3320–3327 (1995).

  72. 72.

    Immun. Today 13, 244–247 (1992).

  73. 73.

    Science 268, 367–368 (1995).

  74. 74.

    EMBO J. 4, 749–753 (1985).

  75. 75.

    Semin. Immun. 6, 373–382 (1994).

  76. 76.

    in Critical Reviews in Immunology (ed. Atassi, Z.) (CRC) (in the press).

  77. 77.

    , & Eur. J. Immun. 24, 1323–1331 (1994).

  78. 78.

    , & J. Immun. 150, 1429–1436 (1993).

  79. 79.

    et al. Proc. natn. Acad. Sci. U.SA. 92, 6484–6488 (1995).

  80. 80.

    , , & Science 268, 403–405 (1995).

  81. 81.

    et al. Eur. J. Immun. 24, 2294–2298 (1994).

  82. 82.

    et al. Int. Immun. 6, 1297–1306 (1994).

  83. 83.

    & Immun. Today 11, 237–244 (1990).

  84. 84.

    et al. Science 246, 666–668 (1989).

  85. 85.

    , & Proc. natn. Acad. Sci. U.S.A. 92, 1649–1653 (1995).

  86. 86.

    & Immun. Res. 6, 57–66 (1987).

  87. 87.

    , , & Immunogenetics 37, 29–38 (1992).

  88. 88.

    , & Immun. Rev. 143, 141–180 (1995).

  89. 89.

    & Nature 335, 167–170 (1988).

  90. 90.

    et al. Nature 329, 506–512 (1987).

Download references

Author information

Affiliations

  1. Departments of Structural Biology and Microbiology & Immunology, Sherman Fairchild Building, Stanford University, Stanford, California 94305, USA

    • Jenny E. Gumperz
    •  & Peter Parham

Authors

  1. Search for Jenny E. Gumperz in:

  2. Search for Peter Parham in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/378245a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.