Article | Published:

The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction

Naturevolume 366pages129135 (1993) | Download Citation

Subjects

Abstract

We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-α/β and -γ signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-α pathway, and between JAK1 and JAK2 in the interferon-γ pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    De Maeyer, E. & De Maeyer-Guignard, J. Interferons and Other Regulatory Cytokines (Wiley, New York, 1988).

  2. 2

    Pestka, S., Langer, T. A., Zoon, K. C. & Samuel, C. E. Rev. Biochem. 56, 727–777 (1987).

  3. 3

    Pellegrini, S. & Schindler, C. Trends Biochem. Sci. 18, 338–342 (1993).

  4. 4

    Fu, X.-F., Schindler, C., Improta, T., Aebersold, R. & Darnell, J. E. Jr Proc. natn. Acad. Sci. U.S.A. 89, 7840–7843 (1992).

  5. 5

    Gutch, M. J., Daly, C. & Reich, N. Proc. natn. Acad. Sci. U.S.A. 89, 11411–11415 (1992).

  6. 6

    Schindler, C., Fu, X.-Y., Improta, T., Aebersold, R. & Darnell, J. E. Jr Proc. natn. Acad. Sci. U.S.A. 89, 7836–7839 (1992).

  7. 7

    Schindler, C., Shuai, K., Prezioso, V. R. & Darnell, J. E. Jr Science 257, 809–813 (1992).

  8. 8

    Veals, S. A. et al. Molec. cell. Biol. 12, 3315–3324 (1992).

  9. 9

    Veals, S. A., Santa Maria, T. & Levy, D. E. Molec. cell. Biol. 13, 196–206 (1993).

  10. 10

    Dale, T. C., Imam, A. M. A., Kerr, I. M. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 86, 1203–1207 (1989).

  11. 11

    Kessler, D. S., Veals, S. A., Fu, X.-Y. & Levy, D. E. Genes Dev. 4, 1753–1755 (1990).

  12. 12

    Levy, D. E., Kessler, D. S., Pine, R. & Darnell, J. E. Jr Genes Dev. 3, 1362–1371 (1989).

  13. 13

    Shuai, K., Schindler, C., Prezioso, V. R. & Darnell, J. E. Jr Science 258, 1808–1812 (1992).

  14. 14

    Müller, M. et al. EMBO J. 12, 4221–4228 (1993).

  15. 15

    Decker, T., Lew, D. J., Mirkovitch, J. & Darnell, J. E. Jr EMB0 J. 10, 927–932 (1991).

  16. 16

    Lew, D. J., Decker, T., Strehlow, I. & Darnell, J. E. Jr Molec. cell. Biol. 11, 182–191 (1991).

  17. 17

    Kanno, Y. et al. Molec. cell. Biol. 13, 3951–3963 (1993).

  18. 18

    Khan, K. D. et al. Proc. natn. Acad. Sci. U.S.A. 90, 6806–6810 (1993).

  19. 19

    Pearse, R. N., Feinman, R., Shuai, K., Darnell, J. E. Jr & Ravetch, J. V. Proc. natn. Acad. Sci. U.S.A. 90, 4314–4318 (1993).

  20. 20

    Perez, C., Wietzerbin, J. & Benech, P. D. Molec. cell. Biol. 13, 2182–2192 (1993).

  21. 21

    Aguet, M., Dembic, Z. & Merlin, G. Cell 55, 273–280 (1988).

  22. 22

    Uzé, G., Lutfalla, G. & Gresser, I. Cell 60, 225–235 (1990).

  23. 23

    Platanias, L. C. & Colamonici, O. R. J. biol. Chem. 267, 24053–24057 (1992).

  24. 24

    Cook, J. R., Jung, V., Schwartz, B., Wang, P. & Pestka. S. Proc. natn. Acad. Sci. U.S.A. 89, 11317–11321 (1992).

  25. 25

    Farrar, M. A., Campbell, J. D. & Schreiber, R. D. Proc. natn. Acad. Sci. U.S.A. 89, 11706–11710 (1992).

  26. 26

    Wilks, A. F. Proc. natn. Acad. Sci. U.S.A. 86, 1603–1607 (1989).

  27. 27

    Wilks, A. F. et al. Molec. cell. Biol. 11, 2057–2065 (1991).

  28. 28

    Harpur, A. G., Andrew, A.-C., Ziemiecki, A., Aston, R. R. & Wilks, A. F. Oncogene 7, 1347–1353 (1992).

  29. 29

    Howard, O. M. Z. et al. Oncogene 7, 895–900 (1992).

  30. 30

    Silvennoinen, O. et al. Proc. natn. Acad. Sci. U.S.A. 90, 8429–8433 (1993).

  31. 31

    Firmbach-Kraft, I., Byers, M., Shows, T., Dalla-Favera, R. & Krolewski, J. J. Oncogene, 5, 1329–1336 (1990).

  32. 32

    Velazquez, L., Fellous, M., Stark, G. R. & Pellegrini, S. Cell 70, 313–322 (1992).

  33. 33

    Pellegrini, S., John, J., Shearer, M., Kerr, I. M. & Stark, G. R. Molec. cell Biol. 9, 4605–4612 (1989).

  34. 34

    McKendry, R. et al. Proc. natn. Acad. Sci. U.S.A. 88, 11455–11459 (1991).

  35. 35

    Pine, R., Decker, T., Kessler, D. S., Levy, D. E. & Darnell, J. E. Jr Molec. cell. Biol. 10, 2448–2457 (1990).

  36. 36

    Sims, S. H. et al. Molec. cell. Biol. 13, 690–702 (1993).

  37. 37

    Bolen, J. B. Oncogene 8, 2025–2031 (1993).

  38. 38

    Argetsinger, L. S. et al. Cell 74, 237–244 (1993).

  39. 39

    Witthuhn, B. A. et al. Cell 74, 227–236 (1993).

  40. 40

    Beyers, A. D., Spruyt, L. L. & Williams, A. F. Trends Cell Biol. 2, 253–255 (1992).

  41. 41

    Weiss, A. Cell 73, 209–212 (1993).

  42. 42

    David, M., Romero, G., Zhang, Z.-Y., Dixon, J. E. & Larner, A. C. J. biol. Chem. 268, 6593–6599 (1993).

  43. 43

    Levy, D. E. & Darnell, J. E. Jr New Biol. 2, 923–928 (1990).

  44. 44

    Stahl, N. & Yancopoulos, G. D. Cell 74, 587–590 (1993).

  45. 45

    Larner, A. C. et al. Science 261, 1730–1733 (1993).

  46. 46

    Ruff-Jamison, S., Chen, K. & Cohen, S. Science 261, 1733–1736 (1993).

  47. 47

    Silvennoinen, O., Schindler, C., Schlessinger, J. & Levy, D. E. Science 261, 1736–1739 (1993).

  48. 48

    Sadowski, H. B., Shuai, K., Darnell, J. E. Jr & Gilman, M. Z. Science 261, 1739–1744 (1993).

  49. 49

    Seed, B. Nature 329, 840–842 (1987).

  50. 50

    Claesson, L., Larhammar, D., Rask, L. & Peterson, P. A. Proc. natn. Acad. Sci. U.SA. 80, 7395–7399 (1983).

  51. 51

    Watling, D. et al. Nature 366, 166–170 (1993).

Download references

Author information

Affiliations

  1. Imperial Cancer Research Fund Laboratories, PO Box 123, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK

    • Mathias Müller
    • , James Briscoe
    • , Carl Laxton
    • , Dmitry Guschin
    •  & lan M. Kerr
  2. Institute for Clinical and Experimental Cancer Research, University of Berne, Tiefenaustrasse 120, 3004, Berne, Switzerland

    • Andrew Ziemiecki
  3. Pharmacology, New York University Medical Center, New York, New York, 10016, USA

    • Olli Silvennoinen
  4. Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Victoria, 3050, Australia

    • Ailsa G. Harpur
    •  & Andrew F. Wilks
  5. Unité INSERM 276, Institut Pasteur, 75724, Paris, Cedex 15, France

    • Giovanna Barbieri
    •  & Sandra Pellegrini
  6. Biochemistry, St Jude Children's Research Hospital, 322 North Lauderdale, Memphis, Tennesee, 38101-0318, USA

    • Bruce A. Witthuhn
    •  & James N. Ihle
  7. Department of Medicine, Columbia University Medical Center, New York, New York, 10032, USA

    • Chris Schindler
  8. Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, 44195, USA

    • George R. Stark

Authors

  1. Search for Mathias Müller in:

  2. Search for James Briscoe in:

  3. Search for Carl Laxton in:

  4. Search for Dmitry Guschin in:

  5. Search for Andrew Ziemiecki in:

  6. Search for Olli Silvennoinen in:

  7. Search for Ailsa G. Harpur in:

  8. Search for Giovanna Barbieri in:

  9. Search for Bruce A. Witthuhn in:

  10. Search for Chris Schindler in:

  11. Search for Sandra Pellegrini in:

  12. Search for Andrew F. Wilks in:

  13. Search for James N. Ihle in:

  14. Search for George R. Stark in:

  15. Search for lan M. Kerr in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/366129a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.