Natural killer cells, viruses and cancer. Cerwenka, A. & Lanier, L. L. Nature Reviews Immunology October (2001).
With the ends in sight: images from the BRCA1 tumor suppressor. Baer, R. Nature Structural Biology October (2001). This News and Views article reports on the recently solved structures of regions of the BRCA1 tumour-suppressor protein. The image — a ribbon diagram of the BRCA1–BARD1 heterodimer complex — is taken from one of the research papers to which this article is linked: Brzovic P. S. et al. Structure of a BRCA1–BARD1 heterodimeric RING–RING complex.
Segmental duplications: an expanding role in genomic instability and disease. Emanuel, B. S. & Shaikh, T. H. Nature Reviews Genetics October (2001).
Catch and pull a microtubule: getting a grasp on the cortex. Allan, V. & Näthke, I. Nature Cell Biology October (2001). A News and Views article that discusses how APC and β-catenin interact with the cytoskeleton to mediate its cortical attachment.
TGF-β signaling in tumor suppression and cancer progression. Derynck, R., Ackhurst R. J. & Balmain, A. Nature Genetics October (2001).
The INK4a/ARF network in tumour suppression. Sherr C. J. Nature Reviews Molecular Cell Biology October (2001).
Redirecting T cell specificity by TCR gene transfer. Moss, P. A. H. Nature Immunology October (2001). This News and Views article describes how genes encoding T-cell receptors can be transferred to T cells using a retroviral delivery system. This allows T cells to be targeted to specific antigens, so, by using tumour-specific receptors, can aid the generation of an effective anti-tumour immune response.
PKB/AKT: functional insights from genetic models. Scheid, M. P. & Woodgett J. R. Nature Reviews Molecular Cell Biology October (2001).
Cell cycle: Archipelago of destruction. Schwab, M. & Tyers, M. Nature 20 September (2001). A News and Views article on three recent papers that identify the F-box protein — hCdc4/Fbw7/Apo — that targets cyclin E for degradation. Cyclin E accumulates in many cancers, which could be because of defects in degradation. In fact, mutations in this F-box gene have been detected in several tumour cell lines.
Rights and permissions
About this article
Cite this article
Reviews and comment from nature journals. Nat Rev Cancer 1, 87 (2001). https://doi.org/10.1038/35094057
Issue Date:
DOI: https://doi.org/10.1038/35094057
This article is cited by
-
Stromal Caveolin-1 Expression in Breast Carcinoma. Correlation with Early Tumor Recurrence and Clinical Outcome
Pathology & Oncology Research (2012)