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Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

Nature volume 306, pages 239–242 (1983)Cite this article

Abstract

The human c-abl oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph′) chromosome, in chronic myelocytic leukaemia (CML). The position of the Ph′ chromosomal break point is shown to be variable and, in one CML patient, has been localized immediately 5′ of, or within, the c-abl oncogene. A DNA restriction fragment corresponding to this site has been molecularly cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22.

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References

  1. Pulciani, S. et al. Nature 300, 539–542 (1982).

    Article  ADS  CAS  Google Scholar 

  2. Der, C. J., Krontiris, T. G. & Cooper, G. M. Proc. natn. Acad. Sci. U.S.A. 79, 3637–3640 (1982).

    Article  ADS  CAS  Google Scholar 

  3. Tabin, C. J. et al. Nature 300, 143–149 (1982).

    Article  ADS  CAS  Google Scholar 

  4. Taparowsky, E. et al. Nature 300, 762–765 (1982).

    Article  ADS  CAS  Google Scholar 

  5. Shimizu, K. et al. Proc. natn. Acad. Sci. U.S.A. 80, 2112–2116 (1983).

    Article  ADS  CAS  Google Scholar 

  6. Collins, S. & Groudine, M. Nature 298, 679–681 (1982).

    Article  ADS  CAS  Google Scholar 

  7. Dalla-Favera, R., Wong-Staal, F. & Gallo, R. Nature 299, 61–63 (1982).

    Article  ADS  CAS  Google Scholar 

  8. Alitalo, K., Schwab, M., Lin, C., Varmus, H. E. & Bishop, J. M. Proc. natn. Acad. Sci. U.S.A. 80, 1707–1711 (1983).

    Article  ADS  CAS  Google Scholar 

  9. de Klein, A. et al. Nature 300, 765–767 (1982).

    Article  ADS  CAS  Google Scholar 

  10. Taub, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7837–7841 (1982).

    Article  ADS  CAS  Google Scholar 

  11. Adams, J. M., Gerondakis, S., Webb, E., Corcoran, L. M. & Cary, S. Proc. natn. Acad Sci. U.S.A. 80, 1982–1986 (1983).

    Article  ADS  CAS  Google Scholar 

  12. Dalla-Favera, R. et al. Science 219, 963–967 (1983).

    Article  ADS  CAS  Google Scholar 

  13. Sheer, D. et al. Proc. natn. Acad. Sci. U.S.A. 80, 5007–5011 (1983).

    Article  ADS  CAS  Google Scholar 

  14. Goff, S. P., Gilboa, E., Witte, O. N. & Baltimore, D. Cell 22, 777–785 (1980).

    Article  CAS  Google Scholar 

  15. Rosenberg, N., Blatimore, D. & Scher, C. Proc. natn. Acad. Sci. U.S.A. 72, 1932–1936 (1975).

    Article  ADS  CAS  Google Scholar 

  16. Abelson, H. T. & Rabstein, L. S. Cancer Res. 30, 2213–2222 (1970).

    CAS  Google Scholar 

  17. Heisterkamp, N., Groffen, J. & Stephenson, J. R. J. molec. appl. Genet. 2, 57–69 (1983).

    CAS  Google Scholar 

  18. Groffen, J., Heisterkamp, N., Reynolds, F. Jr. & Stephenson, J. R. Nature 304, 167–169 (1983).

    Article  ADS  CAS  Google Scholar 

  19. Heisterkamp, N. et al. Nature 299, 747–750 (1982).

    Article  ADS  CAS  Google Scholar 

  20. Rowley, J. D. Nature 243, 290–293 (1973).

    Article  ADS  CAS  Google Scholar 

  21. Lozzio, C. B. & Lozzio, B. B. Blood 45, 321–334 (1975).

    CAS  Google Scholar 

  22. Groffen, J., Heisterkamp, N., Grosveld, G., van de Ven, W. & Stephenson, J. R. Science 216, 1136–1138 (1982).

    Article  ADS  CAS  Google Scholar 

  23. Weinstock, G. M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4432–4436 (1983).

    Article  ADS  CAS  Google Scholar 

  24. Klein, E. et al. Int. J. Cancer 18, 421–431 (1976).

    Article  CAS  Google Scholar 

  25. Hieter, P. A., Hollis, G. F., Korsmeyer, S. J., Waldmann, T. A. & Leder, P. Nature 294, 536–540 (1981).

    Article  ADS  CAS  Google Scholar 

  26. Groffen, J. et al. J. exp. Med. 158, 9–15 (1983).

    Article  CAS  Google Scholar 

  27. Stanton, L. W., Watt, R. & Marcu, K. B. Nature 303, 401–406 (1983).

    Article  ADS  CAS  Google Scholar 

  28. Groffen, J. et al. Nucleic Acids Res. (in the press).

  29. Bartram, C. R. et al. Nature 306, 277–280 (1983).

    Article  ADS  CAS  Google Scholar 

  30. Jeffreys, A. J. & Flavell, R. A. Cell 12, 429–439 (1977).

    Article  CAS  Google Scholar 

  31. Southern, E. M. J. molec. Biol. 98, 503–517 (1975).

    Article  CAS  Google Scholar 

  32. Bernards, R. & Flavell, R. A. Nucleic Acids Res. 8, 1421–1533 (1980).

    Article  Google Scholar 

  33. Groffen, J., Heisterkamp, N., Blennerhassett, G. & Stephenson, J. R. Virology 126, 213–227 (1983).

    Article  CAS  Google Scholar 

  34. Swan, D. C. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4691–4696 (1982).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Viral Carcinogenesis, National Cancer Institute-FCRF, Frederick, Maryland, 21701, USA

    Nora Heisterkamp, John R. Stephenson & John Groffen

  2. Carcinogenesis Intramural Program, Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    Pamela F. Hansen

  3. Department of Cell Biology and Genetics, Erasmus University, PO Box 1738, Rotterdam, 3000 DR, The Netherlands

    Annelies de Klein, Claus R. Bartram & Gerard Grosveld

Authors
  1. Nora Heisterkamp
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  2. John R. Stephenson
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  3. John Groffen
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  4. Pamela F. Hansen
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  5. Annelies de Klein
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  6. Claus R. Bartram
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  7. Gerard Grosveld
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Heisterkamp, N., Stephenson, J., Groffen, J. et al. Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature 306, 239–242 (1983). https://doi.org/10.1038/306239a0

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