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Protamine is an inhibitor of angiogenesis

Abstract

Protamine is shown to be a specific inhibitor of angiogenesis. The compound inhibits the capillary proliferation observed in embryogenesis, inflammation, certain immune reactions and the growth of solid tumours.

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References

  1. Folkman, J. & Cotran, R. S. Int. Rev. exp. Path. 16, 207–248 (1976).

    CAS  Google Scholar 

  2. Gospodarowicz, D. & Thakaral, K. K. Proc. natn. Acad. Sci. U.S.A. 75, 847–851 (1978).

    Article  ADS  CAS  Google Scholar 

  3. Greenberg, G. R. & Hunt, T. K. J. cell. Physiol. 97, 353–360 (1978).

    Article  Google Scholar 

  4. Gimbrone, M. A. Jr, Leapman, S. B., Cotran, R. S. & Folkman, J. J. exp. Med 136, 261–276 (1972).

    Article  Google Scholar 

  5. Folkman, J. Ann. Surg. 175, 409–416 (1972).

    Article  CAS  Google Scholar 

  6. Kessler, D. A., Langer, R. S., Pless, N. A. & Folkman, J. Int. J. Cancer 18, 703–709 (1976).

    Article  CAS  Google Scholar 

  7. Ausprunk, D. H. & Folkman, J. Microvasc. Res. 14, 53–65 (1977).

    Article  CAS  Google Scholar 

  8. Folkman, J., Haudenschild, C. C. & Zetter, B. R. Proc. natn. Acad. Sci. U.S.A. 76, 5217–5221 (1979).

    Article  ADS  CAS  Google Scholar 

  9. Zetter, B. R. Nature 285, 41–43 (1980).

    Article  ADS  CAS  Google Scholar 

  10. Azizkhan, R. G., Azizkhan, J. C., Zetter, B. R. & Folkman, J. J. exp. Med. 152, 931–944 (1980).

    Article  CAS  Google Scholar 

  11. Rosenberg, R. D. & Lam, L. Proc. natn. Acad. Sci. U.S.A. 76, 1218–1222 (1979).

    Article  ADS  CAS  Google Scholar 

  12. Ausprunk, D., Knighton, D. & Folkman, J. Devl Biol. 38, 237–249 (1974).

    Article  CAS  Google Scholar 

  13. Langer, R. & Folkman, J. Nature 263, 797–800 (1976).

    Article  ADS  CAS  Google Scholar 

  14. Langer, R., Brem, H., Falterman, K., Klein, M. & Folkman, J. Science 193, 70–72 (1976).

    Article  ADS  CAS  Google Scholar 

  15. Bronsther, O., Hsieh, D., Gross, J. & Folkman, J. Surg. Forum 32, 426–428 (1981).

    CAS  Google Scholar 

  16. Polverini, P. J., Cotran, R. S., Gimbrone, M. A. Jr & Unanue, E. R. Nature 269, 804–806 (1977).

    Article  ADS  CAS  Google Scholar 

  17. Sidky, Y. A. & Auerbach, R. Science 18, 1237–1238 (1976).

    Article  ADS  Google Scholar 

  18. Fidler, I. J., Gersten, D. M. & Budmen, M. B. Cancer Res. 36, 3160–3165 (1976).

    CAS  Google Scholar 

  19. Muggleton, P. W., MacLaren, J. G. & Kyke, W. S. C. Lancet i, 409–10 (1964).

  20. Dvorak, H. F., Dvorak, A. M., Manseau, E. J., Wiberg, L. & Churchill, W. H. J. natn. Cancer Inst. 62, 1459–1472 (1979).

    CAS  Google Scholar 

  21. Azizkhan, R. G. et al. Surg. Forum 32, 424–426 (1981).

    Google Scholar 

  22. O'Meara, R. A. Q. & O'Halloran, M. J. Lancet ii, 613–614 (1963).

    Article  Google Scholar 

  23. Hughes, L. E. Lancet i, 408–409 (1964).

    Article  Google Scholar 

  24. Lutton, A. Lancet i, 768 (1964).

    Article  Google Scholar 

  25. Pasternak, N. A., Sheinderovitch, B. A., Kolesova, I. A. & Ermoljeva, I. V. Antibiotika 16, 816–819 (1971).

    CAS  Google Scholar 

  26. Csaba, G., Acs, Th., Horvath, c. & Kapa, E. Br. J. Cancer 14, 367–375 (1960).

    Article  CAS  Google Scholar 

  27. Sorgente, N., Kuettner, K. E., Soble, L. W. & Eisenstein, R. Lab. Invest. 32, 217–222 (1975).

    CAS  PubMed  Google Scholar 

  28. Brem, H. & Folkman, J. J. exp. Med 141, 427–439 (1975).

    Article  CAS  Google Scholar 

  29. Langer, R., Conn, H., Vacanti, J., Haudenschild, C. & Folkman, J. Proc. natn. Acad. Sci. U.S.A. 77, 4331–4335 (1980).

    Article  ADS  CAS  Google Scholar 

  30. Goren, S. B., Eisenstein, R. & Choromokos, E. Am. J. Ophthal. 84, 305–309 (1977).

    Article  CAS  Google Scholar 

  31. Patz, A. et al. Ophthalmology 85, 626–637 (1978).

    Google Scholar 

  32. Auerbach, R., Kubai, L., Knighton, D. & Folkman, J. Devl Biol. 41, 391–394 (1974).

    Article  CAS  Google Scholar 

  33. Auerbach, R., Morrissey, L. W. & Sidky, Y. A. Cancer Res. 38, 1739–1744 (1978).

    CAS  PubMed  Google Scholar 

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Taylor, S., Folkman, J. Protamine is an inhibitor of angiogenesis. Nature 297, 307–312 (1982). https://doi.org/10.1038/297307a0

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