Abstract
It is becoming increasingly apparent that interferon exerts a major role in cellular regulatory processes. Besides its well known antiviral properties1, interferon has been shown to affect cell surface antigen expression2,3, lymphoid cell function4,5, as well as cellular protein synthesis6,7 and growth8–11. To date, however, there is little information available on the mechanism of interferon production in vivo except in response to a variety of exogenously administered viral and nonviral systemic inducers. We report here the detection of a pregnancy-associated elevation of interferon, or an interferon-like component, in selected reproductive tissues of mice.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Isaacs, A. & Lindenmann, J. Proc. R. Soc. B147, 258–267 (1957).
Lindahl, P., Leary, P. & Gresser, I. Proc. natn. Acad. Sci. U.S.A. 70, 2785–2788 (1973).
Lindahl, P., Gresser, I., Leary, P. & Tovey, M. Proc. natn. Acad. Sci. U.S.A. 73, 1284–1287 (1976).
Johnson, H. M. & Baron, S. CRC Critical Reviews in Biochemistry 4, 203–227 (1976).
Johnson, H. M. & Baron, S. Pharmac. Ther. A 1, 349–367 (1977).
Brouty-Boye, D., Macieira-Coelho, A., Fiszman, M. & Gresser, I. Int. J. Cancer 12, 250–258 (1973).
Fuse, A. & Kuwata, T. J. gen. Virol. 33, 17–24 (1976).
Paucker, K., Cantell, K. & Henle, W. Virology 17, 324–334, (1962).
Gresser, I. et al. Proc. Soc. exp. Biol. Med. 142, 7–10 (1973).
Dahl, H. & Degré, M. Acta path. microbiol. scand. 84, 285–292 (1976).
Stewart II, W. E., Gresser, I., Tovey, M. G., Bandu, M.-T. & LeGoff, S. Nature 262, 300–302 (1976).
Giron, D. J., Allen, P. T., Pindak, F. F. & Schmidt, J. Appl. Microbiol. 21, 387–393 (1971).
Giron, D. Appl. Microbiol. 18, 584–588 (1969).
Youngner, J. S. & Salvin, S. B. J. Immun. 111, 1914–1922 (1973).
Ho, M., Postic, B. & Yang, H. Ke. in The Systemic Induction of IF, in: CIBA Foundation Symposium on IF (eds Wolstenholme, G. E. W. et al.) 19–35 (Churchill, London, 1967).
Overall Jr., J. C. & Glasgoio, L. A. Science 167, 1139–1141 (1970).
Mendelson, J., Kapusta, R. & Dick, V. Am. J. Obstet. Gynec. 107, 902–907 (1970).
Cembrzynska-Nowak, M. Archs Immun. Ther. Exp. 25, 663–668 (1977).
Jones, B. M. & Kemp, R. B. Nature 221, 829–831 (1969).
Mobraaten, L. E., DeMaeyer, E. & DeMaeyer-Guignard, J. Transplantation 16, 415–420 (1973).
Cerottini, J.-C., Brunner, K. T., Lindahl, P. & Gresser, I. Nature new Biol. 242, 152–153 (1973).
DeMaeyer, E., Mobraaten, L. & DeMaeyer-Guignard, J. C. r. hebd. Séanc. Acad. Sci., Paris 277, 2101–2103 (1973).
Hirsch, M. S., Ellis, D. A., Black, P. H., Monaco, A. P. & Wood, M. L. Transplantation 17, 234–236 (1974).
Hirsch, M. S., Ellis, D. A., Proffitt, M. R. & Black, P. H. Nature new Biol. 244, 102–103 (1973).
DeMaeyer-Guignard, J., Cachard, A. & DeMaeyer, E. Science 190, 574–576 (1975).
DeMaeyer, E., DeMaeyer-Guignard, J. & Vandeputte, M. Proc. natn. Acad. Sci. U.S.A. 72, 1753–1757 (1975).
Lindahl-Magnusson, P., Leary, P. & Gresser, I. Nature new Biol. 237, 120–121 (1972).
Rozee, K. R., Lee, S. H. S. & Ngan, J. Nature new Biol. 245, 16–18 (1973).
Heron, I., Berg, K. & Cantell, K. J. Immun. 117, 1370–1373 (1976).
Giron, D. J., Liu, R. Y., Hemphill, F. E., Pindak, F. F. & Schmidt, J. P. Proc. Soc. exp. Biol. Med. 163, 146–150 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fowler, A., Reed, C. & Giron, D. Identification of an interferon in murine placentas. Nature 286, 266–267 (1980). https://doi.org/10.1038/286266a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/286266a0
This article is cited by
-
Interferon-gamma alters the phagocytic activity of the mouse trophoblast
Reproductive Biology and Endocrinology (2005)
-
Development of the interferon system. I. In chicken cells development in ovo continues on time in vitro
In Vitro Cellular &Developmental Biology (1990)
-
Studies in the in vivo expression of the influenza resistance gene Mx by in-situ hybridisation
Archives of Virology (1990)
-
Regulation of cell growth by interferon
Cancer and Metastasis Review (1987)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.