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Membrane leakiness after viral infection and a new approach to the development of antiviral agents

Nature volume 272, pages 694699 (20 April 1978) | Download Citation

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Abstract

Viral development induces changes in the permeability properties of the plasma membrane of the host cell. Here it is shown that, because of this leakiness, inhibitors of protein synthesis normally impermeable to uninfected cells are able to enter infected cells and thereby specifically inhibit viral protein synthesis.

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Author information

Author notes

    • Luis Carrasco

    Present address: Insto, Bioquimica de Macromoleculas, Centro de Biologia Molecular, Universidad Autónoma de Madrid, Facultad de Ciencias, Canto Blanco, Madrid-34, Spain.

Affiliations

  1. Translation Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2, UK

    • Luis Carrasco

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DOI

https://doi.org/10.1038/272694a0

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