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Blood Group A Antigens on Human Trophoblast Cells

Nature volume 245, pages 329–330 (1973)Cite this article

Abstract

THERE is still no adequate explanation for the fact that the placenta, which is foetal in origin and therefore allogeneic in the mother, is not rejected during pregnancy. A question of fundamental importance is whether human trophoblast cells possess HL-A or ABO antigens. Evidence so far is conflicting1–4. We present evidence which suggests that blood group A antigens may be present on human trophoblast cells, but at low surface density.

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References

  1. Theide, H. A., Choate, J. W., Gardner, H. H., and Santay, H., J. exp. Med., 121, 1039 (1965).

    Article  Google Scholar 

  2. Gross, S. J., Am. J. Obstet. Gynec., 95, 1149 (1966).

    Article  CAS  Google Scholar 

  3. Seigler, H. L., and Metzgar, R. S., Transplantation, 9, 478 (1970).

    Article  CAS  Google Scholar 

  4. Loke, Y. W., Joysey, V. C., and Borland, R., Nature, 232, 403 (1971).

    Article  ADS  CAS  Google Scholar 

  5. Coombs, R. R. A., Bedford, D., and Rouillard, L. M., Lancet, i, 461 (1956).

    Article  Google Scholar 

  6. Sell, K. W., Mori, W., Rack, J. H., Gurner, B. W., and Coombs, R. R. A., Br. J. exp. Path., 50, 413 (1969).

    CAS  Google Scholar 

  7. Kirby, D. R. S., Billington, W. D., Bradbury, S., and Goldstein, D. J., Nature, 204, 548 (1964).

    Article  ADS  CAS  Google Scholar 

  8. Currie, G. A., Van Doorninck, W., and Bagshawe, K. D., Nature, 219, 191 (1968).

    Article  ADS  CAS  Google Scholar 

  9. Coombs, R. R. A., and Franks, D., in Progress in Allergy (edit. by Kallos, P., and Waksman, B. H.), 13, 174 (Karger, Basel, 1969).

    Google Scholar 

  10. Anderson, J. M., Nature's Transplant (Butterworth, London, 1972).

    Google Scholar 

  11. Linscott, W. D., Nature, 228, 824 (1970).

    Article  ADS  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pathology, University of Cambridge,

    Y. W. LOKE & ANNE-CHANTAL BALLARD

Authors
  1. Y. W. LOKE
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  2. ANNE-CHANTAL BALLARD
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LOKE, Y., BALLARD, AC. Blood Group A Antigens on Human Trophoblast Cells. Nature 245, 329–330 (1973). https://doi.org/10.1038/245329a0

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