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Template Activity of Nuclei from Stimulated Lymphocytes

Nature volume 222, pages 1247–1250 (1969)Cite this article

Abstract

Nuclei isolated from human peripheral blood lymphocytes stimulated by phytohaemagglutinin have a greater capacity to prime for nucleotide incorporation into RNA in the presence of exogenous bacterial RNA polymerase than nuclei from unstimulated lymphocytes.

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References

  1. Bond, V. P., Fliedner, T. M., Cronkite, E. P., Rubini, J. R., Brecher, G., and Schork, P. K., Acta Haematol., 21, 1 (1959).

    Article  CAS  PubMed  Google Scholar 

  2. Cooper, E. H., Biochem. J., 78, 21 (1961).

    Google Scholar 

  3. Torelli, U., Grossi, G., Artusi, T., and Emilia, G., Acta Haematol., 30, 129 (1963).

    Article  CAS  PubMed  Google Scholar 

  4. Buckton, K. E., and Pike, M. C., Nature, 202, 714 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Nowell, P. C., Cancer Research, 20, 462 (1960).

    CAS  PubMed  Google Scholar 

  6. Hastings, J., Freedman, S., Rendon, O., Cooper, H. L., and Hirschhorn, K., Nature, 192, 1214 (1961).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. McIntyre, O. R., and Ebaugh, jun., F. G., Blood, 19, 443 (1962).

    CAS  Google Scholar 

  8. Bach, F., and Hirschhorn, K., Exp. Cell Res., 32, 592 (1963).

    Article  CAS  PubMed  Google Scholar 

  9. Bender, M. A., and Prescott, D. M., Exp. Cell Res., 27, 221 (1962).

    Article  CAS  PubMed  Google Scholar 

  10. Frenster, J. H., Allfrey, V. G., and Mirsky, A. E., Proc. US Nat. Acad. Sci., 50, 1026 (1963).

    Article  ADS  CAS  Google Scholar 

  11. Marshall, W. H., and Roberts, K. B., Quart. J. Exp. Physiol., 48, 146 (1963).

    Article  Google Scholar 

  12. Quaglino, D., Hayhoe, F. G. J., and Flemans, R. J., Nature, 196, 338 (1962).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Gropp, A., and Fischer, R., Virchows Arch. Path. Anat., 338, 64 (1964).

    Article  CAS  Google Scholar 

  14. Hirschhorn, R., Kaplan, J. M., Goldberg, A. F., Hirschhorn, K., and Weissmann, G., Science, 147, 55 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Wheelock, E. F., Science, 149, 310 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Coulson, A. S., Quart. J. Exp. Physiol., 50, 271 (1965).

    Article  CAS  PubMed  Google Scholar 

  17. Hirschhorn, R., Hirschhorn, K., and Weissmann, G., Blood, 30, 84 (1967).

    CAS  PubMed  Google Scholar 

  18. Lukas, Z. J., Science, 156, 1237 (1967).

    Article  ADS  Google Scholar 

  19. Loeb, L. A., Agarwal, S. S., and Woodside, A. M., Proc. US Nat. Acad. Sci., 61, 827 (1968).

    Article  ADS  CAS  Google Scholar 

  20. Ripps, C., and Hirschhorn, K., Clin. and Exptl. Immunology, 2, 377 (1967).

    CAS  Google Scholar 

  21. Torelli, U. L., Henry, P. H., and Weissman, S. M., J. Clin. Invest., 47, 1083 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Cooper, H. L., J. Biol. Chem., 243, 34 (1968).

    CAS  PubMed  Google Scholar 

  23. Pogo, B. G. T., Allfrey, V. G., and Mirsky, A. E., Proc. US Nat. Acad. Sci., 55, 805 (1966).

    Article  ADS  CAS  Google Scholar 

  24. Kleinsmith, L. J., Allfrey, V. G., and Mirsky, A. E., Proc. US Nat. Acad. Sci., 55, 1182 (1966).

    Article  ADS  CAS  Google Scholar 

  25. Bonner, J., Dahmus, M. E., Fambrough, D., Wang, R. C., Marushige, K., and Tuan, D. Y. H., Science, 159, 47 (1968).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Allfrey, V. G., Littau, V. C., and Mirsky, A. E., Proc. US Nat. Acad. Sci., 49, 414 (1963).

    Article  ADS  CAS  Google Scholar 

  27. Frenster, J. H., Nature, 206, 680 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  28. Hirschhorn, R., Brittinger, G., Weissmann, G., and Hirschhorn, K., J. Cell Biol., 37, 412 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Brittinger, G., Hirschhorn, R., Hirschhorn, K., and Weissmann, G., J. Cell Biol., 40, 843 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Brittinger, G., Hirschhorn, R., Douglas, S. D., and Weissmann, G., J. Cell Biol., 37, 394 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Weiss, S. B., Proc. US Nat. Acad. Sci., 46, 1020 (1960).

    Article  ADS  CAS  Google Scholar 

  32. Sadowski, P. D., and Steiner, J. W., J. Cell Biol., 32, 147 (1967).

    Google Scholar 

  33. Pogo, A. O., Allfrey, V. G., and Mirsky, A. E., Proc. US Nat. Acad Sci., 56, 550 (1966).

    Article  ADS  CAS  Google Scholar 

  34. Church, R. B., and McCarthy, B. J., J. Mol. Biol., 23, 459 (1967).

    Article  CAS  PubMed  Google Scholar 

  35. Sullivan, D. T., Proc. US Nat. Acad. Sci., 59, 846 (1968).

    Article  ADS  CAS  Google Scholar 

Download references

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Author notes

  1. G. BRITTINGER

    Present address: Medizinische Klinik, Klinikum Essen, Stadt. Krankenanstalten, 43 Essen/Ruhr, Hufelandstr., West Germany

Authors and Affiliations

  1. Departments of Medicine and Environmental Medicine, New York University School of Medicine, New York

    R. HIRSCHHORN, W. TROLL, G. BRITTINGER & G. WEISSMANN

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  1. R. HIRSCHHORN
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  2. W. TROLL
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  3. G. BRITTINGER
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  4. G. WEISSMANN
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HIRSCHHORN, R., TROLL, W., BRITTINGER, G. et al. Template Activity of Nuclei from Stimulated Lymphocytes. Nature 222, 1247–1250 (1969). https://doi.org/10.1038/2221247a0

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