Steric Course of the Succinic Dehydrogenase Catalysed Exchange of Hydrogen between Succinate and Water


SUCCINIC dehydrogenase (succinate: (acceptor) oxido-reductase E.C. catalyses the oxidation of succinate by various electron acceptors to fumarate. Although the mechanism of the reaction is not yet understood, it has been shown1 that the overall process involves removal of one HR- and one HS-atom2 from adjacent carbon atoms of the substrate (Fig. 1a); this corresponds to a trans elimination from the antiperiplanar conformation of succinate, as in Fig. 1b.

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RÉTEY, J., SEIBL, J., ARIGONI, D. et al. Steric Course of the Succinic Dehydrogenase Catalysed Exchange of Hydrogen between Succinate and Water. Nature 216, 1320–1321 (1967).

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