Abstract
PREVIOUSLY1,2 we have shown that guanidine possesses a strong and highly specific inhibitory action against enteroviruses. This antivirus activity of guanidine seemed to us of interest due to: (1) its specificity; (2) the simplicity of guanidine molecule; (3) the ability of guanidine to stop the cytotoxic effect of poliovirus even when added to cell cultures which were infected several hours previously.
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References
Loddo, B., Ferrari, W., Brotzu, G., and Spanedda, A., Nature, 193, 97 (1962).
Loddo, B., Ferrari, W., Brotzu, G., and Spanedda, A., Boll. Ist. Sieroter. Mil., 41, 111 (1962).
Gordon, M. P., Staehelin, M., J. Amer. Chem. Soc., 80, 2340 (1958).
Kovaes, E., Experientia, 14, 295 (1958); 18, 70 (1962).
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LODDO, B., FERRARI, W., SPANEDDA, A. et al. Potentiating Effect of 5-Fluorouracil on the in vitro Antipoliovirus Activity of Guanidine. Nature 197, 408–409 (1963). https://doi.org/10.1038/197408a0
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DOI: https://doi.org/10.1038/197408a0
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