Letter | Published:

Lack of Evidence for a Cholinergic Mechanism in Sympathetic Transmission

Naturevolume 191page86 (1961) | Download Citation



THE nerve supply to many sympathetic effector organs contains cholinergic nerve fibres as well as adrenergic fibres. Recently, the hypothesis has been put forward that a cholinergic mechanism is involved in sympathetic transmission1,2. It has been suggested that acetylcholine released from cholinergic nerve endings liberates from a local tissue store sympathetic transmitter which in turn acts on the effector organ.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Burn, J. H., and Rand, M. J., Nature, 184, 163 (1959).

  2. 2

    Burn, J. H., and Rand, M. J., Brit. J. Pharmacol., 15, 56 (1960).

  3. 3

    Schueler, F. W., J. Pharmacol., 115, 127 (1955).

  4. 4

    MacIntosh, F. C., Birks, R. I., and Sastry, P. B., Nature, 178, 1181 (1956).

  5. 5

    Gardiner, J. E., J. Physiol., 138, 13–14P (1957).

  6. 6

    Rand, M. J., and Chang, V., Nature, 188, 858 (1960).

  7. 7

    Chang, V., and Rand, M. J., Brit. J. Pharmacol., 15, 588 (1960).

  8. 8

    Thompson, J. W., Ph.D. thesis, University of London (1960).

  9. 9

    Wilson, H., and Long, J. P., Arch. Int. Pharmacodyn., 120, 343 (1959).

Download references

Author information


  1. Department of Pharmacology, Institute of Basic Medical Sciences, Royal College of Surgeons of England, Examination Hall, Queen Square, London, W.C.1

    • J. E. GARDINER
    •  & J. W. THOMPSON


  1. Search for J. E. GARDINER in:

  2. Search for J. W. THOMPSON in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.