Abstract
A SPECIES of Cephalosporium produces a hydrophilic penicillin, called cephalosporin N, which yields D-α-aminoadipie acid on hydrolysis1. Crude preparations of cephalosporin N have been found to show strong absorption in ultra-violet light at 260 mμ, although highly purified cephalosporin N shows very little absorption at this wave-length. A new antibiotic with an absorption maximum at 260 mμ has now been isolated from the crude preparations in the form of a crystalline sodium salt. It resembles cephalosporin N in certain physical, chemical and biological properties, but differs from it sharply in others.
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Newton, G. G. F., and Abraham, E. P., Nature, 172, 395 (1953); Biochem. J., 58, 103 (1954).
Thompson, H. W., Brattain, R. R., Randall, H. M., and Rasmussen, R. S., “The Chemistry of Penicillin”, chapter 13 (Princeton University Press, 1949).
Manson, E. E. D., Pollock, M. R., and Tridgell, E. J., J. Gen. Microbiol., 11, 493 (1954).
Pollock, M. R., and Torriani, Anne-Marie, C.R. Acad. Sci., Paris, 237, 276 (1953).
Abraham, E. P., Newton, G. G. F., and Hale, C. W., Biochem. J., 58, 94 (1954).
Gottshall, R. Y., Roberts, J. M., Portwood, L. M., and Jennings, J. C., Proc. Soc. Exp. Biol. Med., 76, 307 (1951).
Abraham, E. P., Newton, G. G. F., Crawford, K., Burton, H. S., and Hale, C. W., Nature, 171, 343 (1953).
Olson, B. H., Jennings, J. C., and Junek, A. J., Science, 117, 76 (1953). Olson, B. H., Jennings, J. C., Pisano, M., and Junek, A. J., Antibiotics and Chemotherapy, 4, 1 (1954).
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NEWTON, G., ABRAHAM, E. Cephalosporin C, a New Antibiotic containing Sulphur and D-α-Aminoadipic Acid. Nature 175, 548 (1955). https://doi.org/10.1038/175548a0
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DOI: https://doi.org/10.1038/175548a0
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