Abstract
IN previous experiments it has been shown that pancreatic glucagon, produced in the A cells of the pancreatic islets1, significantly increases the blood-sugar-level and the urine glucose of intact rats, forcibly fed on a high carbohydrate diet; in these conditions glucagon also augmented the diabetogenic effect of pituitary somatotropic and corticotropic hormones as well as of cortisone. Combined treatment with glucagon and cortisone was the most effective in provoking a temporary diabetic condition2.
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References
Cavallero, C., Medicina (Parma), 2, 223 (1953).
Cavallero, C., and Malandra, B., Acta Endocrinol., 13, 79 (1953).
Sutherland, E. W., Cori, C. F., Haynes, R., and Olsen, A. S., J. Biol. Chem., 180, 825 (1949).
Gomori, G., Amer. J. Path., 15, 497 (1939).
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CAVALLERO, C., MALANDRA, B. & GALANSINO, G. Diabetogenic Action of Pancreatic Glucagon. Nature 173, 585–586 (1954). https://doi.org/10.1038/173585b0
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DOI: https://doi.org/10.1038/173585b0
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