A SUBSTANCE that proved to be Δ9-etiocholenol-3(α)-one-17 (II) was isolated by Lieberman et al.1 from the urine of certain patients with cancer of the breast or prostate, lymphatic leukæmia, essential hypertension or Cushing's syndrome. They suggested that Δ9-etiocholenol-3(α)-one-17 was a derivative of 11-hydroxy-etiocholanol-3(α)-one-17 (I) and was formed from the latter compound by dehydration during the acid hydrolysis of the urine. Later, they were able to identify (I) in urinary extracts by infrared spectroscopy2.
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DINGEMANSE, E., IN 'T VELD, L. Isolation of II-Hydroxy-etiocholanol-3(α)-one-17 from the Urine of Male Patients with Adrenal Cancer. Nature 164, 844 (1949). https://doi.org/10.1038/164844a0
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