Trichothecin : an Antifungal Metabolic Product of Trichothecium roseum Link

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ANTAGONISTIC activity to other fungi by Trichothecium roseum Link (syn. Cephalothecium roseum Corda) has been reported by Whetzel1, Boning2, Koch3 and Greaney and Machacek4. Culture filtrates of T. roseum have been shown to inhibit germination of Botrytis allii conidia5. We have isolated the substance responsible for this activity in crystalline form in yields of 20–30 mgm. per litre of culture filtrate. The name ‘trichothecin' is suggested for the active substance.

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  1. 1

    Whetzel, H. H., Ont. Nat. Sci. Bull., 5, 3 (1909).

  2. 2

    Boning, K., Phytopath. Z., 6, 113 (1933).

  3. 3

    Koch, L. W., Sci. Agric., 15, 80 (1934).

  4. 4

    Greaney, F. J., and Machacek, J. E., Sci. Agric., 15, 377 (1935).

  5. 5

    Brian, P. W., and Hemming, H. G., J. Gen. Microbiol., 1, 158 (1947).

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FREEMAN, G., MORRISON, R. Trichothecin : an Antifungal Metabolic Product of Trichothecium roseum Link. Nature 162, 30 (1948) doi:10.1038/162030a0

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