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A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921

The Journal of Antibiotics volume 76, pages 706–710 (2023)Cite this article

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Abstract

The filamentous fungus Synnemellisia sp. strain FKR-0921 was obtained from soil collected on Kume Island, Okinawa. The MeOH extract of FKR-0921 cultured on a solid rice medium yielded a new aromatic compound, synnemellisitriol A (1). The structure, including the absolute configuration, was elucidated by spectroscopic analysis (FT-IR, NMR, and HR-ESI-MS), and the absolute configuration at C-9 of 1 was determined using the modified Mosher’s method. Additionally, 1 was evaluated for its biological activities, including metallo-β-lactamase inhibitory activity, type III secretion system inhibitory activity, antimicrobial activity, antimalarial activity, and cytotoxicity.

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Acknowledgements

We are grateful to Mr. Shinichi Gima (Center for Research Advancement and Collaboration, University of the Ryukyus) for the HR-ESI-MS measurements. We are grateful to the distinguished Emeritus Professor Satoshi Ōmura (Kitasato University) for his helpful support, valuable guidance, and insightful suggestions. Furthermore, we acknowledge the English language editing provided by Editage (www.editage.com). This study was supported by the Okinawan Create Leading Projects in Growing Fields 2017–2019, Okinawan Create Leading Projects in Growing Fields 2020–2021, and OKINAWA Prefectural Government. This research was partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) from AMED under Grant Numbers JP21am0101096 (Phase I) and JP22ama121035 (Phase II).

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Authors and Affiliations

  1. Department of Biosciences and Biotechnology, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan

    Arisu Tahara, Kazuki Tani, Miyu Wakatsuki & Takahiro Ishii

  2. Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Toshiyuki Tokiwa, Mayuka Higo, Kenichi Nonaka, Tomoyasu Hirose, Rei Hokari, Aki Ishiyama, Masato Iwatsuki, Yoshihiro Watanabe, Masako Honsho, Yukihiro Asami, Hidehito Matsui, Toshiaki Sunazuka & Hideaki Hanaki

  3. Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan

    Toshiaki Teruya

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Correspondence to Takahiro Ishii.

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41429_2023_657_MOESM1_ESM.docx

<b>S1</b>. Spectral data of <b>1</b>; <b>Figure S1-1</b>~<b>Figure S1-8</b>: <b>S2</b>; <b>Figure S2-1</b>~<b>Figure S2-2</b>

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Tahara, A., Tani, K., Wakatsuki, M. et al. A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921. J Antibiot 76, 706–710 (2023). https://doi.org/10.1038/s41429-023-00657-4

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