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Antimalarial lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete Ganoderma sp.

The Journal of Antibiotics volume 73, pages 702–710 (2020)Cite this article

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Abstract

Ten previously undescribed lanostane-type triterpenoids (1–10), together with 15 known lanostanes, were isolated from artificially cultivated fruiting bodies of the basidiomycete Ganoderma sp. BCC 21329. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data and by application of the modified Mosher’s method. Compounds 1, 3, 5, and 7 showed moderate antimalarial activity (IC50 3.8–7.6 μg ml−1).

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Acknowledgements

Joint research grant from Thailand Research Fund (grant No. DBG6280008) and National Natural Science Foundation of China (grant No. 21961142008) are gratefully acknowledged.

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Authors and Affiliations

  1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, 12120, Thailand

    Masahiko Isaka, Malipan Sappan & Wilunda Choowong

  2. National Biobank of Thailand, 114 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, 12120, Thailand

    Thitiya Boonpratuang & Rattaket Choeyklin

  3. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China

    Tao Feng & Ji-Kai Liu

Authors
  1. Masahiko Isaka
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  2. Malipan Sappan
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  3. Wilunda Choowong
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  4. Thitiya Boonpratuang
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  5. Rattaket Choeyklin
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  6. Tao Feng
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  7. Ji-Kai Liu
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Correspondence to Masahiko Isaka.

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Isaka, M., Sappan, M., Choowong, W. et al. Antimalarial lanostane triterpenoids from cultivated fruiting bodies of the basidiomycete Ganoderma sp.. J Antibiot 73, 702–710 (2020). https://doi.org/10.1038/s41429-020-0357-7

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  • DOI: https://doi.org/10.1038/s41429-020-0357-7

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