Abstract
The powerful inhibitory action of 5-amino-2-butoxypyridine on the growth of Mycobacteria, which is highly specific for members of that genus, has recently been reported1,2. Strains of M. tuberculosis (including the human-type H37Rv) and M. phlei were inhibited at dilutions of this compound so high as 0·03-0·001 mgm. per cent in Dorset's synthetic or in Proskauer–Beck medium, inoculation being either on the surface by a small piece of pellicle or by a suspension of about 20,000 organisms per ml.
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References
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Feinstone, W. H., Friedman, H. L., Rothlauf, M. V., Kelly, A. M., and Williams, R. D., J. Pharmacol, 89, 153 (1947).
Dubos, R. J., and Davis, B. D., J. Exp. Med., 83, 409 (1946).
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FORREST, H., HART, P. & WALKER, J. Antagonistic Effect by Certain Growth-Stimulants of the Tuberculostatic Activity of 5-Amino-2-butoxypyridine. Nature 160, 94 (1947). https://doi.org/10.1038/160094a0
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DOI: https://doi.org/10.1038/160094a0
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