Abstract
ALTHOUGH it is now many years since myristicin was first isolated from the oils of nutmeg and mace, its synthesis has not previously been recorded. Its constitution was established by H. Thoms in 19031 as 3-methoxy-4 : 5-methylenedioxy-l-allylbenzene, a molecule suitably orientated for its use as the starting point in the successful syntheses of cotarnine by Salway2 and by Becker and Decker3.
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References
Thoms, H., Ber., 36, 3446 (1903).
Salway, J. Chem. Soc., 97, 1208 (1910).
Decker and Becker, Annalen, 395, 328 (1913).
Perkin and Trikojus, J. Chem. Soc., 1663 (1927).
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TRIKOJUS, V., WHITE, D. Synthesis of Myristicin. Nature 144, 1016 (1939). https://doi.org/10.1038/1441016b0
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DOI: https://doi.org/10.1038/1441016b0
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