Abstract
IN a previous communication1 we described the œstrogenic activity of 4: 4'-dihydroxy-α: β-diethylstilbene (diethylstilbœstrol). It was shown that this substance was fully œstrogenic in doses of 0·004 mgm. given subcutaneously dissolved in oil, and 0·001 mgm. when given by mouth. It is thus several times more potent than œstrone and at least as potent as œstradiol. The following communication is concerned with the activity of a series of compounds in which substituents other than the ethyl group are attached to the α and β carbon atoms. The method of testing was on ovariectomized rats by the usual technique.
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Dodds, Golberg, Lawson and Robinson, NATURE, 141, 247 (1938).
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DODDS, E., GOLBERG, L., LAWSON, W. et al. Œstrogenic Activity of Alkylated Stilœstrols. Nature 142, 34 (1938). https://doi.org/10.1038/142034a0
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DOI: https://doi.org/10.1038/142034a0
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