Featured
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Outline |
How to vaccinate the world next time
Experts discuss the lessons learnt from COVID-19 and the challenge of preparing the world for the next global pandemic.
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World View |
Even after COVID, the world’s vaccine strategy is failing
Without a global, publicly funded strategy, the market will fail to deliver vaccines to stop pandemics before they surge.
- Seth Berkley
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Nature Index |
How the pandemic inspired a new generation of creators
The COVID-19 crisis echoed the ‘all-hands-on-deck’ response to the Second World War, but such agility needs to be maintained.
- Chris Woolston
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Article
| Open AccessAntibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination
Pre-existing high-affinity antibodies alter germinal centre and memory B cell selection by lowering the activation threshold for B cells and through direct masking of their cognate epitopes, thereby permitting a diverse set of abundant lower-affinity clones targeting alternate epitopes to participate in the immune response.
- Dennis Schaefer-Babajew
- , Zijun Wang
- & Michel C. Nussenzweig
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Article
| Open AccessFXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
FXR regulates the levels of ACE2 in tissues of the respiratory and gastrointestinal systems that are affected by COVID-19, and inhibiting FXR with ursodeoxycholic acid downregulates ACE2 and reduces susceptibility to SARS-CoV-2 infection.
- Teresa Brevini
- , Mailis Maes
- & Fotios Sampaziotis
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Nature Index |
Strength in the life sciences sustains US advantage
Generous funding, desirable locations, COVID-19 vaccine development and established intercity links are helping three cities to stand out.
- Neil Savage
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News |
Dengue vaccine poised for roll-out but safety concerns linger
Indonesia will be using the jab from next year, but some scientists say there are insufficient data to rule out that it could make infections worse in some people.
- Smriti Mallapaty
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News |
Can mRNA vaccines transform the fight against Ebola?
On the heels of successful COVID-19 mRNA vaccines, the technology could hold promise in protecting against another deadly pathogen.
- Max Kozlov
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News |
COVID vaccine hoarding might have cost more than a million lives
Low- and middle-income nations would have had lower death rates if vaccines had been shared more equitably.
- Heidi Ledford
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News Round-Up |
Volcano charges, Omicron boosters and wandering elephants
The latest science news, in brief.
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News |
Omicron boosters could arm you against variants that don’t yet exist
Worries that the immune system would get ‘stuck’ on the original SARS-CoV-2 strain are dispelled by laboratory experiments.
- Sara Reardon
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News |
COVID prompts global surge in labs that handle dangerous pathogens
India, Singapore and the Philippines are among those building new laboratories certified as biosafety level 3 or above, but some researchers worry about the costs and risks.
- Smriti Mallapaty
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News Feature |
COVID jabs for kids: they’re safe and they work — so why is uptake so patchy?
Some countries are now offering COVID vaccines for children as young as six months. Nature looks at how effective they are and why more kids haven’t had them.
- Smriti Mallapaty
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News Explainer |
Will there be a COVID winter wave? What scientists say
Emerging variants and waning immunity are likely to push infection rates higher in the Northern Hemisphere as influenza also makes a comeback.
- Ewen Callaway
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News |
Japan’s $2-billion initiative to prep pandemic vaccines in 100 days
A new centre will invest in shots for a range of infectious diseases so the country is ready for future outbreaks.
- Smriti Mallapaty
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Article |
Long-primed germinal centres with enduring affinity maturation and clonal migration
Using HIV Env protein immunogen priming in rhesus monkeys followed by a long period without further immunization, we demonstrate germinal centre B cells lasting at least 6 months, showing promise in regard to difficult vaccine targets.
- Jeong Hyun Lee
- , Henry J. Sutton
- & Shane Crotty
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News |
Malaria vaccine booster prolongs protection
Vaccine candidate provides two years of protection in young children when given as a booster, but larger trials are needed before it can be rolled out.
- Heidi Ledford
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News |
China and India approve nasal COVID vaccines — are they a game changer?
Scientists hope the immunizations, delivered through the nose or mouth, will prevent even mild cases of illness.
- Emily Waltz
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Correspondence |
Equitable drug access: small-scale manufacturing units can help
- Rachel Chikwamba
- , Kerry R. Love
- & Filippo Randazzo
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News Feature |
How nasal-spray vaccines could change the pandemic
Vaccines inhaled through the mouth or nose might stop the coronavirus in its tracks, although there’s little evidence from human trials so far.
- Emily Waltz
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World View |
Don’t lose sight of monkeypox containment
Although case counts might be dropping, the public-health community must focus on containing the epidemic completely.
- Caitlin Rivers
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News |
COVID vaccines slash risk of spreading Omicron — and so does previous infection
But the benefit of vaccines in reducing Omicron transmission doesn’t last for long.
- Ruby Prosser Scully
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News Explainer |
Spate of polio outbreaks worldwide puts scientists on alert
Cases of paralysis in the United States and Israel suggest vaccine-derived poliovirus has infected many people.
- Heidi Ledford
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News Explainer |
Which COVID boosters to take and when: a guide for the perplexed
A diverse menu of vaccine options leaves people searching for the best route to protection.
- Heidi Ledford
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News |
Should parents delay kids’ second COVID vaccine? Here’s what the research says
Increasing the interval between the first two mRNA-vaccine doses might boost children’s immunity, but it is a gamble as a new variant sweeps the globe.
- Shannon Hall
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Editorial |
Get childhood immunizations back on track after COVID
The effects of the pandemic mean childhood vaccination rates are the lowest for a generation. There is a risk of preventable diseases resurging unless governments treat this as a priority.
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News |
Pandemic drives largest drop in childhood vaccinations in 30 years
Last year alone, 25 million children missed out on immunizations against infections such as measles and polio, leading to avoidable outbreaks of disease.
- Giorgia Guglielmi
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News |
Monkeypox declared a global emergency: will it help contain the outbreak?
The window for containment is rapidly closing, researchers say.
- Max Kozlov
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Research Highlight |
Lassa-fever vaccine confers fast protection in animals
Primates given an experimental jab against the virus are less susceptible to illness after only a few days.
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News |
COVID immunity, 3D nucleus — the week in infographics
Nature highlights three key graphics from the week in science and research.
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Editorial |
Why a vaccine hub for low-income countries must succeed
A new initiative aims to shift the dangerous imbalance in access to medicines, laid bare by the COVID-19 pandemic. It deserves support.
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News |
Guatemala’s COVID vaccine roll-out failed: here’s what researchers know
Missteps in connecting with Indigenous communities factored into the nation’s low vaccination rate.
- Luke Taylor
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News Feature |
Did COVID vaccine mandates work? What the data say
A measure of last resort got a major workout during the pandemic. Scientists are now trying to determine whether the benefits outweighed the potential damage to public trust.
- Liam Drew
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News |
China’s first mRNA vaccine is close — will that solve its COVID woes?
Researchers say a highly effective jab will help to avoid hospitals getting overwhelmed, but probably won’t end the country’s ‘zero COVID’ policy.
- Yvaine Ye
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News Explainer |
What Omicron’s BA.4 and BA.5 variants mean for the pandemic
The lineages’ rise seems to stem from their ability to infect people who were immune to earlier forms of Omicron and other variants.
- Ewen Callaway
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News |
FDA authorizes COVID vaccines for the littlest kids: what the data say
The Moderna and Pfizer shots are hard to compare, so researchers and parents have lingering questions.
- Cassandra Willyard
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Nature Careers Podcast |
Science in Africa: lessons from the COVID-19 pandemic
The continent followed Western nations too closely in its early response to the coronavirus emergency, says Nigerian virologist Oyewale Tomori.
- Dom Byrne
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News |
Flu vaccine could cut COVID risk
Health-care workers who got the influenza vaccine were also protected from COVID-19 — but the effect might not last long.
- Ewen Callaway
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Nature Podcast |
Coronapod: ‘viral ghosts’ support idea that SARS-CoV-2 reservoirs could be behind long COVID
Viral fragments in the gut, found lingering months after infection, are offering tantalizing new hints as to the causes of long COVID.
- Noah Baker
- & Heidi Ledford
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News |
Kids get limited COVID protection from world’s most popular vaccines
First analyses of two Chinese-made vaccines in young children show that the shots do provide 60–65% effectiveness against hospitalization.
- Smriti Mallapaty
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Nature Podcast |
Coronapod: COVID and diabetes, what the science says
According to a massive study, even mild COVID can significantly increase the risk of developing type 2 diabetes
- Noah Baker
- & Nicky Phillips
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Nature Podcast |
Audio long-read: The quest to prevent MS — and understand other post-viral diseases
Researchers are investigating why some people infected with Epstein-Barr virus go on to develop multiple sclerosis, and what can be done to prevent it.
- Asher Mullard
- & Benjamin Thompson
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Article
| Open AccessIncreased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost
A third dose of an mRNA vaccine against SARS-CoV-2 results in an expanded B cell repertoire that produces antibodies with increased potency and breadth.
- Frauke Muecksch
- , Zijun Wang
- & Michel C. Nussenzweig
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News Round-Up |
COVID’s diabetes risk, vaccine rankings and hidden industry ties
The latest science news, in brief.
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Nature Podcast |
Coronapod: infected immune cells hint at cause of severe COVID
Immune cells infected with COVID trigger massive inflammatory response, according to new studies.
- Noah Baker
- & Smriti Mallapaty
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News Round-Up |
Funny paper titles, COVID immunity and carbon storage
The latest science news, in brief.
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News |
Straight-swimming bacteria and recycling CO2 — the week in infographics
Nature highlights three key graphics from the week in science and research.