Protein vaccines articles within Nature

Featured

  • Article |

    The structures of the open and closed states of the Omicron spike protein and its complex with the ACE2 receptor or a broadly neutralizing antibody are resolved and shed light on the receptor engagement and antibody neutralization of Omicron.

    • Qin Hong
    • , Wenyu Han
    •  & Yao Cong

  • Article |

    Systemic genome-led vaccinology and a mouse model of Trypanosoma vivax infection identify protective invariant subunit vaccine antigens, and demonstrate the possibility of generating effective vaccines that induce long-lasting protection against trypanosome infections.

    • Delphine Autheman
    • , Cécile Crosnier
    •  & Gavin J. Wright

  • Article |

    Immunization of macaques with nanoparticle-conjugated receptor-binding domain of SARS-CoV-2 adjuvanted with 3M-052 and alum results in cross-neutralizing antibodies against bat coronaviruses, SARS-CoV and SARS-CoV-2 variants, and may provide a platform for developing pan-coronavirus vaccines.

    • Kevin O. Saunders
    • , Esther Lee
    •  & Barton F. Haynes

  • Article |

    The immunogen RC1 facilitates recognition of the V3-glycan patch on the envelope of HIV-1 and elicits specific serological responses in mice and macaques, making it a possible priming immunogen for sequential vaccination strategies in humans.

    • Amelia Escolano
    • , Harry B. Gristick
    •  & Michel C. Nussenzweig

  • Article |

    Monoclonal antibodies isolated from patients with dengue virus infection also bind to the Zika virus E protein and neutralize both Zika and dengue virus infection; the structures of two of these antibodies in complex with the Zika virus envelope protein define the binding determinants of the epitope and identify the structural basis of antibody cross neutralization.

    • Giovanna Barba-Spaeth
    • , Wanwisa Dejnirattisai
    •  & Félix A. Rey

  • Letter |

    The new entry inhibitor eCD4-Ig, consisting of the immunoadhesin form of CD4 (CD4-Ig) fused to a small CCR5-mimetic sulfopeptide, avidly binds two highly conserved sites of the HIV-1 Env protein; the inhibitor has high potency and breadth and can neutralize 100% of a diverse panel of neutralization-resistant HIV-1 viruses, and when delivered to macaques using an adeno-associated virus vector, it can provide effective long-term protection from multiple challenges with simian/human immunodeficiency virus.

    • Matthew R. Gardner
    • , Lisa M. Kattenhorn
    •  & Michael Farzan

  • Article |

    A crystal structure of the human immunodeficiency virus Env trimer, used by the virus to infect cells, is determined here; the new structure, which shows the pre-fusion form of Env, increases our understanding of the fusion mechanism and of how the conformation of Env allows the virus to evade the immune response.

    • Marie Pancera
    • , Tongqing Zhou
    •  & Peter D. Kwong

  • Article |

    Computational protein design methods are used to generate new candidates for a human respiratory syncytial virus (RSV) vaccine; artificial protein scaffolds that mimic the structure of a RSV epitope are shown to induce RSV-specific neutralizing antibodies in macaques.

    • Bruno E. Correia
    • , John T. Bates
    •  & William R. Schief

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