Applied immunology articles within Nature

Featured

  • Article |

    Two malaria vaccines comprising Plasmodium falciparum sporozoites and treatment with either pyrimethamine or chloroquine induced durable protective responses against both the African vaccine strain and a heterologous South American strain of P. falciparum.

    • Agnes Mwakingwe-Omari
    • , Sara A. Healy
    •  & Patrick E. Duffy

  • Article |

    Rapid extracellular antigen profiling of a cohort of 194 individuals infected with SARS-CoV-2 uncovers diverse autoantibody responses that affect COVID-19 disease severity, progression and clinical and immunological characteristics.

    • Eric Y. Wang
    • , Tianyang Mao
    •  & Aaron M. Ring

  • Letter |

    A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.

    • Theodore L. Roth
    • , Cristina Puig-Saus
    •  & Alexander Marson

  • Letter |

    Introducing chimeric antigen receptors into the endogenous T-cell receptor locus reduces tonic signalling, averts accelerated T-cell differentiation and delays T-cell exhaustion, leading to enhanced function and anti-tumour efficacy compared to random integrations.

    • Justin Eyquem
    • , Jorge Mansilla-Soto
    •  & Michel Sadelain

  • Outlook |

    • Herb Brody

  • Outlook |

    The advent of routine childhood vaccination has led to dramatic declines in many contagious diseases in the United States. Maintaining these gains there and spreading these successes worldwide are major public-health challenges. By Tony Scully.

    • Tony Scully

  • Outlook |

    Malaria, HIV/AIDS and tuberculosis are humanity's deadliest foes, and have stymied vaccinologists for centuries. New technology and ideas could finally make a difference.

    • Katherine Bourzac

  • Outlook |

    China is poised to become a major global vaccine maker, but first it must overcome serious problems with quality control.

    • Priya Shetty

  • Outlook |

    Extreme temperatures damage vaccines. Efforts are underway to find better ways to deliver the goods.

    • Neil Savage

  • Outlook |

    We must push harder to eliminate diseases, for everyone's benefit, say Andrew Artenstein and Gregory Poland.

    • Andrew W. Artenstein
    •  & Gregory A. Poland

  • Outlook |

    Klaus Stöhr asks whether those responsible for public health will grasp new opportunities to ensure pandemic vaccine readiness.

    • Klaus Stöhr

  • Outlook |

    Faced with outbreaks of preventable diseases, public-health experts need to win over parents who refuse vaccinations.

    • Michael Eisenstein

  • News |

    Success of Chinese biotech partnership raises hopes for prevention of overlooked diseases.

    • Soo Bin Park

  • News & Views |

    A genetic analysis of viruses infecting participants in an HIV vaccine trial indicates that the vaccine is more protective against viruses that have variations at specific sites in the viral envelope. See Letter p.417

    • David V. Glidden

  • Letter |

    Indian rhesus macaques are vaccinated with simian immunodeficiency virus (SIV)-restricted CD8+ T-cell epitopes, and these vaccinated animals are shown to mediate elite control of virus replication.

    • Philip A. Mudd
    • , Mauricio A. Martins
    •  & David I. Watkins

  • Outlook |

    Two vaccines seem to be so effective in preventing HPV infection that mass vaccination has been introduced for girls. But will long-term studies show falls in cervical cancer?

    • Julie Clayton

  • Outlook |

    Vaccines on the market aren't practical for the developing world — where cervical cancer hits hardest — but researchers are trying to make ones that are.

    • Katharine Sanderson

  • Outlook |

    The nearly century-long search for a malaria vaccine might end in the bottom of a cup.

    • Sarah DeWeerdt

  • News Feature |

    For decades, Robert Daum has studied the havoc wreaked by methicillin-resistant Staphylococcus aureus. Now he thinks he can stop it for good.

    • Maryn McKenna

  • News & Views |

    The structure of an antibody that potently neutralizes a wide range of HIV-1 strains, together with a minimal antigen mimic, is an advance towards the design of vaccines that may elicit protective responses. See Article p.336

    • Quentin J. Sattentau

  • News |

    As outbreak enters its second year, relief bodies move to roll out vaccine for the first time.

    • Declan Butler

  • News |

    An antibody that recognizes all strains of influenza A could be a universal vaccine blueprint.

    • Marian Turner

  • Outlook |

    After a decade of disappointments, hopes for a successful Alzheimer's vaccine that ameliorates symptoms and ultimately prevents the disease are rising again.

    • Jim Schnabel

  • News Q&A |

    Diseases such as malaria and HIV still present a major challenge to vaccine development, says Gates foundation's departing global-health chief.

    • Erika Check Hayden

  • Outlook |

    The hepatitis C virus has a set of cunning ways to evade immunity, but researchers are turning the immune system on it.

    • Michael Eisenstein

  • News & Views |

    Developing AIDS vaccines has been a frustrating business. A vaccine that triggers immune responses that effectively control early infection by the simian counterpart of HIV in macaques seems promising. See Letter p.523

    • R. Paul Johnson

  • News |

    First affordable and effective weapon against killer meningococcal meningitis A rolled out in Africa.

    • Declan Butler

  • News |

    A way to nail down the shape of a viral protein segment could spur vaccine development.

    • Alla Katsnelson

  • Outlook |

    Recent successes are reinvigorating research into a vaccine for HIV, reports Cassandra Willyard.

    • Cassandra Willyard

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