Urological cancer

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  • Research | | open

    In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.

    • Julia F. Hopkins
    • , Veronica Y. Sabelnykova
    • , Joachim Weischenfeldt
    • , Ronald Simon
    • , Jennifer A. Aguiar
    • , Rached Alkallas
    • , Lawrence E. Heisler
    • , Junyan Zhang
    • , John D. Watson
    • , Melvin L. K. Chua
    • , Michael Fraser
    • , Francesco Favero
    • , Chris Lawerenz
    • , Christoph Plass
    • , Guido Sauter
    • , John D. McPherson
    • , Theodorus Kwast
    • , Jan Korbel
    • , Thorsten Schlomm
    • , Robert G. Bristow
    •  & Paul C. Boutros
  • Reviews |

    Owing to the limited operating space available, robot-assisted approaches have been rapidly adopted for procedures involving the retroperitoneal space. In this Review the authors describe the outcomes of patients undergoing robot-assisted procedures, including partial nephrectomy, radical nephrectomy, retroperitoneal lymph node dissection, nephroureterectomy and adrenalectomy, in addition to the potential of novel techniques.

    • Wesley W. Ludwig
    • , Michael A. Gorin
    • , Phillip M. Pierorazio
    •  & Mohamad E. Allaf
  • Reviews |

    The clinical relevance of variant histology in urinary bladder cancer has been increasing, resulting in new classifications of urothelial cancers by the WHO in 2016 and highlighting the importance of an accurate morphological description of pathological specimens for the therapeutic management of patients with bladder cancer.

    • Marco Moschini
    • , David D'Andrea
    • , Stephan Korn
    • , Yasin Irmak
    • , Francesco Soria
    • , Eva Compérat
    •  & Shahrokh F. Shariat
  • Reviews |

    WNT signalling pathway components are potentially important in prostate tumours, particularly in the development of castration-resistant prostate cancer and in the prostate tumour microenvironment. Here, Murillo-Garzón and Kypta describe our current understanding of WNT signalling in prostate cancer and discuss the potential of drugs that target this pathway.

    • Virginia Murillo-Garzón
    •  & Robert Kypta

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