Renal cancer

Definition

Renal cancer refers to all malignancies that occur within the kidney. Subtypes include renal cell carcinoma and Wilms tumours.

Latest Research and Reviews

  • Reviews |

    Renal cell carcinoma (RCC) is largely percieved to be radioresistant, owing to the failure of several clinical trials involving fractionated radiotherapy. However, following the availability of new technologies, which enable the delivery of ablative doses of radiation, in fewer fractions, excellent responses have been observed among patients with RCC. In this Review, the authors describe the evidence supporting the use of ablative-dose radiotherapy, either alone, or in combination with other therapies in patients with RCC.

    • Shankar Siva
    • , Gargi Kothari
    • , Alexander Muacevic
    • , Alexander V. Louie
    • , Ben J. Slotman
    • , Bin S. Teh
    •  & Simon S. Lo
  • Research | | open

    Renal cell carcinoma (RCC) is a common and aggressive malignancy. Here, the authors generate two mouse models of the most common RCC subtypes: the human papillary RCC through MYC activation and clear cell RCC through MYC activation combined with Vhl and Cdkn2a deletion.

    • Sean T. Bailey
    • , Aleisha M. Smith
    • , Jordan Kardos
    • , Sara E. Wobker
    • , Harper L. Wilson
    • , Bhavani Krishnan
    • , Ryoichi Saito
    • , Hyo Jin Lee
    • , Jing Zhang
    • , Samuel C. Eaton
    • , Lindsay A. Williams
    • , Ujjawal Manocha
    • , Dorien J. Peters
    • , Xinchao Pan
    • , Thomas J. Carroll
    • , Dean W. Felsher
    • , Vonn Walter
    • , Qing Zhang
    • , Joel S. Parker
    • , Jen Jen Yeh
    • , Richard A. Moffitt
    • , Janet Y. Leung
    •  & William Y. Kim
  • Research |

    Nazneen Rahman, Geert Kops and colleagues report the identification of biallelic loss-of-function mutations in TRIP13 in six individuals with Wilms tumor who presented with features of mosaic variegated aneuploidy. They show that TRIP13-mutant cells show spindle assembly checkpoint defects and suggest that mechanisms leading to aneuploidy may contribute directly to increased cancer risk.

    • Shawn Yost
    • , Bas de Wolf
    • , Sandra Hanks
    • , Anna Zachariou
    • , Chiara Marcozzi
    • , Matthew Clarke
    • , Richarda M de Voer
    • , Banafsheh Etemad
    • , Esther Uijttewaal
    • , Emma Ramsay
    • , Harriet Wylie
    • , Anna Elliott
    • , Susan Picton
    • , Audrey Smith
    • , Sarah Smithson
    • , Sheila Seal
    • , Elise Ruark
    • , Gunnar Houge
    • , Jonathon Pines
    • , Geert J P L Kops
    •  & Nazneen Rahman
  • Research |

    Through combined deletion of Vhl, Trp53 and Rb1 in renal epithelial cells, the authors develop a new mouse model of renal cell carcinoma that recapitulates the cellular and molecular features of a large proportion of human tumors. This model uncovers a role for primary-cilium-related genes in the development of the disease and provides a reliable platform for preclinical therapeutic studies.

    • Sabine Harlander
    • , Désirée Schönenberger
    • , Nora C Toussaint
    • , Michael Prummer
    • , Antonella Catalano
    • , Laura Brandt
    • , Holger Moch
    • , Peter J Wild
    •  & Ian J Frew
  • Reviews |

    Clear cell renal cell carcinoma is associated with reprogramming of metabolic pathways including glucose and fatty acid metabolism and the tricarboxylic acid cycle. Here, the authors discuss these reprogrammed pathways and the opportunities they provide for new therapies, imaging modalities and biomarkers.

    • Hiromi I. Wettersten
    • , Omran Abu Aboud
    • , Primo N. Lara Jr
    •  & Robert H. Weiss
  • Research | | open

    Cell lines are central to cancer research, but knowing which cell lines are the best representative of actual tumours is a major challenge. Here the authors provide a resource assessment of 65 renal cell lines to assist researchers in selecting suitable lines for studying specific renal carcinoma subtypes.

    • Rileen Sinha
    • , Andrew G. Winer
    • , Michael Chevinsky
    • , Christopher Jakubowski
    • , Ying-Bei Chen
    • , Yiyu Dong
    • , Satish K. Tickoo
    • , Victor E. Reuter
    • , Paul Russo
    • , Jonathan A. Coleman
    • , Chris Sander
    • , James J. Hsieh
    •  & A. Ari Hakimi