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| Open AccessMechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase
- O. Lidor
- , A. Al-Quntar
- & D. Steinberg
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| Open AccessTetrathiomolybdate mediates cisplatin-induced p38 signaling and EGFR degradation and enhances response to cisplatin therapy in gynecologic cancers
- Kyu Kwang Kim
- , Alex Han
- & Richard G. Moore
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| Open AccessChemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery
- Anupam Pradhan
- , Geoffrey H. Siwo
- & Dennis E. Kyle
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| Open AccessSystems pharmacology-based dissection of mechanisms of Chinese medicinal formula Bufei Yishen as an effective treatment for chronic obstructive pulmonary disease
- Jiansheng Li
- , Peng Zhao
- & Yonghua Wang
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| Open AccessNovel anticancer agent, SQAP, binds to focal adhesion kinase and modulates its activity
- Jesus Izaguirre-Carbonell
- , Hirofumi Kawakubo
- & Fumio Sugawara
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| Open AccessNatural small molecule FMHM inhibits lipopolysaccharide-induced inflammatory response by promoting TRAF6 degradation via K48-linked polyubiquitination
- Ke-Wu Zeng
- , Li-Xi Liao
- & Peng-Fei Tu
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| Open AccessLeveraging existing data sets to generate new insights into Alzheimer’s disease biology in specific patient subsets
- Kevin D. Fowler
- , Jason M. Funt
- & Fadi Towfic
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| Open AccessFormation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity
- Wen Zhang
- , Min Chen
- & Yan Xu
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| Open AccessIdentification of agents effective against multiple toxins and viruses by host-oriented cell targeting
- Leeor Zilbermintz
- , William Leonardi
- & Mikhail Martchenko
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| Open AccessSelective targeting of PPARγ by the natural product chelerythrine with a unique binding mode and improved antidiabetic potency
- Weili Zheng
- , Lin Qiu
- & Yong Li
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| Open AccessGenetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation
- Valeria Tomati
- , Elvira Sondo
- & Nicoletta Pedemonte
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| Open AccessLarge-scale Direct Targeting for Drug Repositioning and Discovery
- Chunli Zheng
- , Zihu Guo
- & Yonghua Wang
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| Open AccessNovel drug target identification for the treatment of dementia using multi-relational association mining
- Thanh-Phuong Nguyen
- , Corrado Priami
- & Laura Caberlotto
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| Open AccessMetabonomic analysis of potential biomarkers and drug targets involved in diabetic nephropathy mice
- Tingting Wei
- , Liangcai Zhao
- & Hongchang Gao
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| Open AccessComprehensive prediction of drug-protein interactions and side effects for the human proteome
- Hongyi Zhou
- , Mu Gao
- & Jeffrey Skolnick
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| Open AccessFunctional Identification of Target by Expression Proteomics (FITExP) reveals protein targets and highlights mechanisms of action of small molecule drugs
- Alexey Chernobrovkin
- , Consuelo Marin-Vicente
- & Roman A. Zubarev
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| Open AccessThe cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress
- Ping Lu
- , Marieke H. Heineke
- & Dirk Bald
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| Open AccessProgranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice
- Yun-peng Zhao
- , Qing-yun Tian
- & Chuan-ju Liu
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| Open AccessHDL surface lipids mediate CETP binding as revealed by electron microscopy and molecular dynamics simulation
- Meng Zhang
- , River Charles
- & Gang Ren
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| Open AccessProtopanaxatriol, a novel PPARγ antagonist from Panax ginseng, alleviates steatosis in mice
- Yu Zhang
- , Lijing Yu
- & Cheng Huang
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| Open AccessGluCl a target of indole alkaloid okaramines: a 25 year enigma solved
- Shogo Furutani
- , Yuri Nakatani
- & Kazuhiko Matsuda
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| Open AccessDisruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival
- Silke Fuchs
- , Ermelinda Rende
- & Tony Nolan
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| Open AccessPharmacological targeting of the β-amyloid precursor protein intracellular domain
- Caterina Branca
- , Ilenia Sarnico
- & Marina Pizzi
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| Open AccessChemical signatures and new drug targets for gametocytocidal drug development
- Wei Sun
- , Takeshi Q. Tanaka
- & Wei Zheng
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| Open AccessNetwork Understanding of Herb Medicine via Rapid Identification of Ingredient-Target Interactions
- Hai-Ping Zhang
- , Jian-Bo Pan
- & Zhi-Liang Ji
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| Open AccessOral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice
- Akio Matsumoto
- , Megumi Yamafuji
- & Haruaki Nakaya
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| Open AccessCD72 regulates the growth of KIT-mutated leukemia cell line Kasumi-1
- Tatsuki R. Kataoka
- , Atsushi Kumanogoh
- & Hironori Haga
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| Open AccessInhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule
- Sarah J. Welsh
- , Aaron G. Dale
- & Stephen Neidle
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| Open AccessThe ClC-3 chloride channel associated with microtubules is a target of paclitaxel in its induced-apoptosis
- Haifeng Zhang
- , Huarong Li
- & Lixin Chen
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| Open AccessInduction of Pax3 gene expression impedes cardiac differentiation
- Qiao Li
- , Melanie Le May
- & Jihong Chen
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| Open AccessMicrotubule Alterations Occur Early in Experimental Parkinsonism and The Microtubule Stabilizer Epothilone D Is Neuroprotective
- Daniele Cartelli
- , Francesca Casagrande
- & Graziella Cappelletti
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| Open AccessThe embalmed heart of Richard the Lionheart (1199 A.D.): a biological and anthropological analysis
- Philippe Charlier
- , Joël Poupon
- & Geoffroy Lorin de la Grandmaison
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| Open AccessSecreted Threonyl-tRNA synthetase stimulates endothelial cell migration and angiogenesis
- Tamara F. Williams
- , Adam C. Mirando
- & Karen M. Lounsbury
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| Open AccessInhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-κB/HIF-1α signaling pathway
- Hee Jung Kim
- , Jae Seok Jeong
- & Yong Chul Lee
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| Open AccessBlockade of CD47 increases survival of mice exposed to lethal total body irradiation
- David R. Soto-Pantoja
- , Lisa A. Ridnour
- & David D. Roberts
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| Open AccessRelease of Cyclic Phosphatidic Acid from Gelatin-based Hydrogels Inhibit Colon Cancer Cell Growth and Migration
- Tamotsu Tsukahara
- & Kimiko Murakami-Murofushi
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| Open AccessDiosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice
- Chihiro Tohda
- , Takuya Urano
- & Tomoharu Kuboyama
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| Open AccessHypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors
- Alexis Bretteville
- , François Marcouiller
- & Emmanuel Planel
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| Open AccessTRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse
- Lauri J. Moilanen
- , Mirka Laavola
- & Eeva Moilanen
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| Open AccessIdentification of links between small molecules and miRNAs in human cancers based on transcriptional responses
- Wei Jiang
- , Xiaowen Chen
- & Xia Li