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| Open AccessIntegrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome
- Robert Moore
- , Bhanwar Lal Puniya
- & Tomáš Helikar
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| Open AccessGenome-wide CRISPR/Cas9-knockout in human induced Pluripotent Stem Cell (iPSC)-derived macrophages
- Elena Navarro-Guerrero
- , Chwen Tay
- & Daniel Ebner
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| Open AccessDevelopment of a target identification approach using native mass spectrometry
- Miaomiao Liu
- , Wesley C. Van Voorhis
- & Ronald J. Quinn
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| Open AccessMycobacterium tuberculosis Rv3160c is a TetR-like transcriptional repressor that regulates expression of the putative oxygenase Rv3161c
- Hasan Tükenmez
- , Souvik Sarkar
- & Christer Larsson
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| Open AccessErythrocyte sphingosine kinase regulates intraerythrocytic development of Plasmodium falciparum
- Raj Kumar Sah
- , Soumya Pati
- & Shailja Singh
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| Open AccessMechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol’s metabolite KH176m
- X. Jiang
- , H. Renkema
- & J. Beyrath
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| Open AccessNovel use of a chemically modified siRNA for robust and sustainable in vivo gene silencing in the retina
- Takazumi Taniguchi
- , Ken-ichi Endo
- & Masaaki Kageyama
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| Open AccessCharacterization of the erythrocyte GTPase Rac1 in relation to Plasmodium falciparum invasion
- Silvio Paone
- , Sarah D’Alessandro
- & Anna Olivieri
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| Open AccessHigh-throughput screening to discover inhibitors of the CarD·RNA polymerase protein–protein interaction in Mycobacterium tuberculosis
- Maxwell A. Stefan
- , Glory M. Velazquez
- & George A. Garcia
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| Open AccessPhotoacoustic in vivo 3D imaging of tumor using a highly tumor-targeting probe under high-threshold conditions
- Hisatsugu Yamada
- , Natsuki Matsumoto
- & Teruyuki Kondo
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| Open AccessPreclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs
- Saee Paliwal
- , Alex de Giorgio
- & Alix MB Lacoste
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| Open AccessA network pharmacology-based approach to explore potential targets of Caesalpinia pulcherima: an updated prototype in drug discovery
- Nikhil S. Sakle
- , Shweta A. More
- & Santosh N. Mokale
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| Open AccessA membrane transporter determines the spectrum of activity of a potent platinum–acridine hybrid anticancer agent
- Xiyuan Yao
- , Noah H. Watkins
- & Ulrich Bierbach
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Article
| Open AccessEpigenetics meets GPCR: inhibition of histone H3 methyltransferase (G9a) and histamine H3 receptor for Prader–Willi Syndrome
- David Reiner
- , Ludwig Seifert
- & Holger Stark
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| Open AccessProlongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans
- Dagmar Pretsch
- , Judith Maria Rollinger
- & Alexander Pretsch
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Article
| Open AccessPiperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
- Gracielle C. de Almeida
- , Luiz F. S. Oliveira
- & Jose G. Abreu
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| Open AccessNumerical evaluation of spray position for improved nasal drug delivery
- Saikat Basu
- , Landon T. Holbrook
- & Julia S. Kimbell
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Article
| Open AccessPeriostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy
- Yuki Kubo
- , Keijiro Ishikawa
- & Shigeo Yoshida
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| Open AccessDevelopment of 177Lu-scFvD2B as a Potential Immunotheranostic Agent for Tumors Overexpressing the Prostate Specific Membrane Antigen
- Debora Carpanese
- , Guillermina Ferro-Flores
- & Laura Meléndez-Alafort
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Article
| Open AccessLandscape of immune cell gene expression is unique in predominantly WHO grade 1 skull base meningiomas when compared to convexity
- Zsolt Zador
- , Alexander P. Landry
- & Michael D. Cusimano
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Article
| Open AccessThe aryl hydrocarbon receptor pathway controls matrix metalloproteinase-1 and collagen levels in human orbital fibroblasts
- Elisa Roztocil
- , Christine L. Hammond
- & Collynn F. Woeller
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Article
| Open AccessInhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression
- Li-Wen Shen
- , Man-Qing Qian
- & Wen Zhang
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| Open AccessNucleic acid recognition and antiviral activity of 1,4-substituted terphenyl compounds mimicking all faces of the HIV-1 Rev protein positively-charged α-helix
- Cristina Medina-Trillo
- , Daniel M. Sedgwick
- & José Gallego
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| Open AccessAnti-CD81 antibodies reduce migration of activated T lymphocytes and attenuate mouse experimental colitis
- Takuya Hasezaki
- , Tadahiko Yoshima
- & Yukiko Mine
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| Open AccessSoyasapogenol-A targets CARF and results in suppression of tumor growth and metastasis in p53 compromised cancer cells
- Amr Omar
- , Rajkumar Singh Kalra
- & Renu Wadhwa
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| Open AccessFasentin diminishes endothelial cell proliferation, differentiation and invasion in a glucose metabolism-independent manner
- Mª Carmen Ocaña
- , Beatriz Martínez-Poveda
- & Miguel Ángel Medina
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| Open AccessDifferential kinase activity of ACVR1 G328V and R206H mutations with implications to possible TβRI cross-talk in diffuse intrinsic pontine glioma
- Hongnan Cao
- , Miao Jin
- & Jeffrey Skolnick
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| Open AccessCRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models
- Anurag Rathore
- , Sho Iketani
- & David D. Ho
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| Open AccessJanus effect of glucocorticoids on differentiation of muscle fibro/adipogenic progenitors
- Andrea Cerquone Perpetuini
- , Giulio Giuliani
- & Gianni Cesareni
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| Open AccessA semisynthetic borrelidin analogue BN-3b exerts potent antifungal activity against Candida albicans through ROS-mediated oxidative damage
- Hao Su
- , Caijuan Hu
- & Xueshi Huang
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| Open AccessImproving detection of protein-ligand binding sites with 3D segmentation
- Marta M. Stepniewska-Dziubinska
- , Piotr Zielenkiewicz
- & Pawel Siedlecki
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Article
| Open AccessPiscidin-1 Induces Apoptosis via Mitochondrial Reactive Oxygen Species-Regulated Mitochondrial Dysfunction in Human Osteosarcoma Cells
- Meng-Hsuan Cheng
- , Chieh-Yu Pan
- & Hsiao-Mei Kuo
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Article
| Open AccessNintedanib ameliorates animal model of dermatitis
- Min-Jeong Heo
- , Chanmi Lee
- & Jin Hyuk Jung
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Article
| Open AccessAngiotensin-[1–7] attenuates kidney injury in experimental Alport syndrome
- Hong Sang Choi
- , In Jin Kim
- & Eun Hui Bae
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| Open AccessPaclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation
- Anthony M. Cirrincione
- , Adriana D. Pellegrini
- & Sandra Rieger
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| Open AccessGenome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide
- Shumpei Tateno
- , Midori Iida
- & Yuki Yamaguchi
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| Open AccessA simple and effective method to discern the true commercial Chinese cordyceps from counterfeits
- Fu-Li Zhang
- , Xiao-Feng Yang
- & Jun Song
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Article
| Open AccessThe kinase polypharmacology landscape of clinical PARP inhibitors
- Albert A. Antolin
- , Malaka Ameratunga
- & Bissan Al-Lazikani
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Article
| Open AccessBergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease
- Vincenzo Musolino
- , Micaela Gliozzi
- & Arun J. Sanyal
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| Open AccessVitis vinifera polyphenols from seedless black fruit act synergistically to suppress hepatotoxicity by targeting necroptosis and pro-fibrotic mediators
- Marwa M. Abu-Serie
- & Noha H. Habashy
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| Open AccessHigh-throughput identification of post-transcriptional utrophin up-regulators for Duchenne muscle dystrophy (DMD) therapy
- Emanuele Loro
- , Kasturi Sengupta
- & Tejvir S. Khurana
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| Open AccessScreening of potential miRNA therapeutics for the prevention of multi-drug resistance in cancer cells
- Zdravka Medarova
- , Pamela Pantazopoulos
- & Byunghee Yoo
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Article
| Open AccessIsolation and identification of two pairs of cytotoxic diterpene tautomers and their tautomerization mechanisms
- Li-Ping Dai
- , Xiao-Fei Li
- & Zhi-Min Wang
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| Open AccessA Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment
- Anne-Cécile Guyot
- , Charlotte Leuxe
- & Aloïse Mabondzo
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| Open AccessMass spectrometry-based metabolomics approach in the isolation of bioactive natural products
- Daniel P. Demarque
- , Renata G. Dusi
- & Laila S. Espindola
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| Open AccessA Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules
- Natasha L. Patel-Murray
- , Miriam Adam
- & Ernest Fraenkel
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| Open AccessFlavanomarein inhibits high glucose-stimulated epithelial-mesenchymal transition in HK-2 cells via targeting spleen tyrosine kinase
- Nan-nan Zhang
- , Jin-sen Kang
- & Xin-min Mao
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| Open AccessTargeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson’s disease with dementia
- Deepthi Yedlapudi
- , Liping Xu
- & Aloke K. Dutta
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| Open AccessCharacterization of cancer omics and drug perturbations in panels of lung cancer cells
- Ayako Suzuki
- , Keiichi Onodera
- & Katsuya Tsuchihara