Systems biology articles within Nature Reviews Cardiology

Featured

  • Review Article |

    In this Review, Jo and colleagues discuss blood flow-induced mechanisms involved in endothelial cell dysfunction and atherosclerosis, including the emerging concept of disturbed-flow-induced reprogramming of endothelial cells as a pro-atherogenic mechanism, and highlight the therapeutic potential of targeting of flow-sensitive genes, proteins and pathways.

    • Ian A. Tamargo
    • , Kyung In Baek
    •  & Hanjoong Jo

  • Review Article |

    The autonomic nervous system profoundly affects the function of the cardiovascular and immune systems. In this Review, Carnevale summarizes how the neural regulation of immunity and inflammation participates in the onset and progression of cardiovascular disease and explores promising opportunities for therapeutic strategies.

    • Daniela Carnevale

  • Comment |

    Dietary supplementation with NAD+ precursors or ketone esters has been shown to improve mitochondrial function in preclinical models of heart failure with either reduced or preserved ejection fraction. Both supplementation approaches hold promise but are in the early stages of development as clinical therapies for heart failure.

    • Kevin D. O’Brien
    •  & Rong Tian

  • Review Article |

    In this Review, Fernandez and Giannarelli discuss how single-cell technologies can advance our understanding of the cellular and molecular composition of atherosclerotic plaques and how these approaches can guide the design of new, personalized immunotherapies and immune monitoring tools for the management of patients with atherosclerotic cardiovascular disease.

    • Dawn M. Fernandez
    •  & Chiara Giannarelli

  • Review Article |

    Atherosclerotic plaque erosion is becoming an increasingly common characteristic of culprit lesions in acute coronary syndromes. In this Review, Fahed and Jang discuss the patient phenotype and the molecular characteristics in plaque erosion and provide their vision for a potential major shift in the management of patients with plaque erosion.

    • Akl C. Fahed
    •  & Ik-Kyung Jang

  • Review Article |

    In this Review, Mayr and colleagues describe the growing number of omic techniques, discuss their strengths and weaknesses, outline network theory, and highlight exemplars of novel approaches that combine gene regulatory and co-expression networks, proteomics, metabolomics, lipidomics and phenomics with informatics techniques to provide new insights into cardiovascular disease.

    • Abhishek Joshi
    • , Marieke Rienks
    •  & Manuel Mayr

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