Featured
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Review Article |
Profiling joint tissues at single-cell resolution: advances and insights
In this Review, Pandey and Bhutani describe the use of single-cell ‘omics’ technologies to identify cell subpopulations in joint tissues in health and disease, thereby contributing to the construction of joint cell atlases and the identification of pathogenetic cell subpopulations that are potential therapeutic targets for diseases such as osteoarthritis and rheumatoid arthritis.
- Akshay Pandey
- & Nidhi Bhutani
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Review Article |
The non-coding RNA interactome in joint health and disease
Non-coding RNAs such as microRNAs, long non-coding RNAs and circular RNAs regulate signalling pathways that are important in joint development, homeostasis and disease. A better understanding of the non-coding RNA interactome could lead to new therapies for joint diseases.
- Shabana A. Ali
- , Mandy J. Peffers
- & Mohit Kapoor
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Comment |
Mapping the musculoskeletal system one cell at a time
The Human Cell Atlas (HCA) project aims to map tissues and organs during development, maturation and pathology at single cell resolution. The musculoskeletal HCA network is a community for fostering collaboration and shared expertise to help develop the therapeutic approaches needed to address the high global burden of musculoskeletal disorders.
- Mathew J. Baldwin
- , Adam P. Cribbs
- & Sarah J. B. Snelling
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Research Highlight |
Single-cell analysis identifies key pathways and prognostic markers in lupus nephritis
- Ellen F. Carney
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Review Article |
Single-cell technologies — studying rheumatic diseases one cell at a time
Single-cell sequencing technologies enable transcriptomic, epigenomic and proteomic analysis of rare or heterogeneous populations of cells. In this Review, Kuo and colleagues discuss current and future uses of single-cell sequencing technologies for rheumatology research.
- Peggie Cheung
- , Purvesh Khatri
- & Alex J. Kuo
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Review Article |
Insights into rheumatic diseases from next-generation sequencing
Next-generation sequencing (NGS) technologies are being developed at a rapid pace. This Review highlights advances in our understanding of rheumatic diseases that have been gained from NGS and offers guidance to rheumatology researchers using these technologies.
- Laura T. Donlin
- , Sung-Ho Park
- & Lionel B. Ivashkiv
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Review Article |
Sequencing the functional antibody repertoire—diagnostic and therapeutic discovery
Next-generation sequencing is at the forefront of the identification and characterization of clonal families of antibodies that are involved in immune responses to infection, cancer and autoimmune disease. In this article, cutting-edge antibody repertoire sequencing technologies are described as a means of paving the way forward for research and discovery in rheumatology.
- William H. Robinson
Low-frequency and rare genetic variants associated with rheumatoid arthritis risk
Newly defined pro-inflammatory DC subset expanded in SLE
Functionally distinct fibroblast subsets in RA