Featured
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Article
| Open AccessComputational imaging of moving objects obscured by a random corridor via speckle correlations
The authors demonstrate an approach for imaging moving objects through a tortuous corridor filled with a random media. Their reduced spatial- and ensemble-speckle intensity correlation method allows for reconstruction of centimeter-sized hidden object with sub-millimeter resolution.
- Tian Shi
- , Liangsheng Li
- & Ning Zheng
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Article
| Open AccessInstant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology
Diagnosis of gastric cancer currently requires gastroscopic biopsy, which requires time and expertize to perform. Here, the authors demonstrate a femto-SRS imaging method which showed high accuracy in diagnosing gastric cancer without the need for pathologistbased diagnosis.
- Zhijie Liu
- , Wei Su
- & Minbiao Ji
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Article
| Open AccessEnhancing fibre-optic distributed acoustic sensing capabilities with blind near-field array signal processing
Here, the authors demonstrate a blind and sparse near-field array signal processing approach to enhance the measurement quality of fibre-optic distributed acoustic sensors. It further enables the accurate estimation of the spatial coordinates of acoustic sources.
- Felipe Muñoz
- & Marcelo A. Soto
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Article
| Open AccessWavelength-multiplexed hook nanoantennas for machine learning enabled mid-infrared spectroscopy
Infrared spectroscopy with plasmonic nanoantennas is limited by small overlap between molecules and hot spots, and sharp resonance peaks. The authors demonstrate spectral multiplexing of hook nanoantennas with gradient dimensions as ultrasensitive vibrational probes in a continuous ultra-broadband region and utilize machine learning for enhanced sensing performance.
- Zhihao Ren
- , Zixuan Zhang
- & Chengkuo Lee
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Article
| Open AccessInvestigating water/oil interfaces with opto-thermophoresis
Charging of interfaces between water and hydrophobic media is a mysterious feature whose nature and origin remain under debate. Here, the authors use opto-thermophoretic tweezers to investigate the interfacial behavior at water/oil interfaces in terms of thermal perturbation of dipole arrangement.
- Youngsun Kim
- , Hongru Ding
- & Yuebing Zheng
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Article
| Open AccessSurface plasmons induce topological transition in graphene/α-MoO3 heterostructures
Hyperbolic phonon polaritons – mixed states of photons and anisotropic lattice vibrations – offer appealing properties for nanophotonic applications. Here, the authors show that the plasmon-phonon hybridization upon electronic doping in graphene/α-MoO3 heterostructures can induce topological transitions of the polariton wavefront.
- Francesco L. Ruta
- , Brian S. Y. Kim
- & D. N. Basov
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Article
| Open AccessPixel super-resolution with spatially entangled photons
Pixelation is common in quantum imaging systems and limit the image spatial resolution. Here, the authors introduce a pixel super-resolution approach based on measuring the full spatially-resolved joint probability distribution of spatially-entangled photons, and improve pixel resolution by a factor two.
- Hugo Defienne
- , Patrick Cameron
- & Daniele Faccio
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Article
| Open AccessLow-noise frequency-agile photonic integrated lasers for coherent ranging
Stable and tunable integrated lasers are fundamental building blocks for applications from spectroscopy to imaging and communication. Here the authors present a narrow linewidth hybrid photonic integrated laser with low frequency noise and fast linear wavelength tuning. They then provide an efficient FMCW LIDAR demonstration.
- Grigory Lihachev
- , Johann Riemensberger
- & Tobias J. Kippenberg
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Article
| Open AccessTerahertz thermal curve analysis for label-free identification of pathogens
A label-free sensing method has been developed for identifying hazardous pathogens based on their intrinsic properties. This was possible by interrogating the temperature-dependent dielectric constant of the microbes in the far-infrared range.
- S. W. Jun
- & Y. H. Ahn
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Article
| Open AccessPhoton-free (s)CMOS camera characterization for artifact reduction in high- and super-resolution microscopy
Pixel-to-pixel variations in sCMOS cameras lead to image artifacts in widefield fluorescence microscopy, and algorithmic corrections require thorough camera characterization. Here, the authors present an open source automated pipeline for camera characterization based solely on thermally generated signal.
- Robin Diekmann
- , Joran Deschamps
- & Jonas Ries
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Article
| Open AccessHigh-resolution two-dimensional electronic spectroscopy reveals the homogeneous line profile of chromophores solvated in nanoclusters
Understanding the interaction of single chromophores with nanoparticles remains a challenging task in nanoscience. Here the authors provide insight into the interaction between isolated base-free phthalocyanine molecules and He and Ne nanoclusters in the gas phase using high-resolution two-dimensional spectroscopy.
- Ulrich Bangert
- , Frank Stienkemeier
- & Lukas Bruder
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Article
| Open AccessCompact light field photography towards versatile three-dimensional vision
Light field imaging typically requires large format detectors and yet often compromises resolution or speed. Here, compact light field photography is presented to lift both restrictions to see through and around severe occlusions in 3D and real time.
- Xiaohua Feng
- , Yayao Ma
- & Liang Gao
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Article
| Open AccessA boundary migration model for imaging within volumetric scattering media
Imaging in scattering media is challenging due to signal attenuation and strong coupling of scattered and signal photons. The authors present a boundary migration model of the scattered field, converting scattered measurements in spectral form to scene information in temporal domain, and image Lambertian objects in highly scattering media.
- Dongyu Du
- , Xin Jin
- & Jingyan Song
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Article
| Open AccessDeep learning enables reference-free isotropic super-resolution for volumetric fluorescence microscopy
Volumetric fluorescence microscopy is often limited by anisotropic spatial resolution. Here, the authors present an unsupervised deep-learning approach that enhances axial resolution by learning from high-resolution lateral images, and demonstrate isotropic resolution and restoration of suppressed visual details.
- Hyoungjun Park
- , Myeongsu Na
- & Jong Chul Ye
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Article
| Open AccessDual chirped microcomb based parallel ranging at megapixel-line rates
Photonic integrated systems can be harnessed for fast and efficient optical telecommunication and metrology technologies. Here the authors develop a dual-soliton microcomb technique for massively parallel coherent laser ranging that requires only a single laser and a single photoreceiver.
- Anton Lukashchuk
- , Johann Riemensberger
- & Tobias J. Kippenberg
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Article
| Open AccessPixel-level Bayer-type colour router based on metasurfaces
Though metasurface-based 3D colour routers are attractive for next-generation colour imaging systems, their complex fabrication and poor performance remain a bottleneck. Here, the authors use the inverse-design method to realize high performance metasurface-based Bayer-type colour routers.
- Xiujuan Zou
- , Youming Zhang
- & Zhenlin Wang
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Article
| Open AccessObservation of a phase transition within the domain walls of ferromagnetic Co3Sn2S2
In the Bloch or Neel domain walls in ferromagnets, the magnetization rotates smoothly from up to down, preserving its magnitude. Here, Lee et al show that Co3Sn2S2 exhibits a phase transition within its domain walls to a state in which the magnetization passes through zero rather than rotating as the wall is traversed.
- Changmin Lee
- , Praveen Vir
- & Joseph Orenstein
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Article
| Open AccessAchieving low-power single-wavelength-pair nanoscopy with NIR-II continuous-wave laser for multi-chromatic probes
The authors introduce stimulated-emission induced excitation depletion (STExD) nanoscopy using a single pair of low-power, near-infrared, continue-wave lasers. Emission of multichromatic probes is inhibited by cascade amplified depletion in lanthanide upconversion systems induced by manipulating their common sensitizer.
- Xin Guo
- , Rui Pu
- & Qiuqiang Zhan
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Article
| Open AccessFast raster-scan optoacoustic mesoscopy enables assessment of human melanoma microvasculature in vivo
Raster-Scanning-Optoacoustic Mesoscopy can be used to image the vasculature in skin cancer lesions but is limited by a long exposure time. Here; the authors increase the speed of the imaging using co-axial illumination and a high-sensitivity ultrasound detector path.
- Hailong He
- , Christine Schönmann
- & Vasilis Ntziachristos
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Article
| Open AccessUltra-compact snapshot spectral light-field imaging
The authors demonstrate compact spectral light-field imaging by using a transversely dispersive metalens array and a monochrome imaging sensor. They show that 4D images can be obtained in a single shot, and demonstrate discrimination of visually indistinguishable objects.
- Xia Hua
- , Yujie Wang
- & Shining Zhu
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Article
| Open AccessDual-comb thin-disk oscillator
Achieving high output powers in dual-comb sources is important for possible applications like deep UV high resolution spectroscopy. Here the authors demonstrate a fully passive scheme of generating a set of high-power dual-combs from a thin-disc gain medium.
- Kilian Fritsch
- , Tobias Hofer
- & Oleg Pronin
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Article
| Open AccessEvanescent scattering imaging of single protein binding kinetics and DNA conformation changes
Single molecule detection based on evanescent illumination usually require specially designed nanomaterials. Here, the authors show that single molecule detection can be realised on a plain glass surface via interference between the evanescent lights scattered by molecules and the natural roughness of the glass.
- Pengfei Zhang
- , Lei Zhou
- & Shaopeng Wang
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Article
| Open AccessA synergistic strategy to develop photostable and bright dyes with long Stokes shift for nanoscopy
Super-resolution microscopy is a powerful tool for cellular studies but requires bright and stable fluorescent probes. Here, the authors report on a strategy to introduce quinoxaline motifs to conventional probes to make them brighter, more photostable, larger Stokes shift, and demonstrate the probes for biosensing applications.
- Gangwei Jiang
- , Tian-Bing Ren
- & Lin Yuan
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Article
| Open AccessDual-comb photothermal spectroscopy
'Recent developments in spectroscopy have witnessed the establishment of dual-comb techniques. In this work the authors demonstrate dual-comb photothermal spectroscopy providing gas sensing with superfine resolution and high sensitivity
- Qiang Wang
- , Zhen Wang
- & Wei Ren
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Article
| Open AccessIntracavity Raman scattering couples soliton molecules with terahertz phonons
Here, the authors demonstrate intra-cavity excitation and time-domain sampling of coherent optical phonons inside an active laser oscillator. They discover that Terahertz crystal vibrations link successive ultrashort solitons which offers an approach to highspeed Raman spectroscopy inside laser cavities.
- Alexandra Völkel
- , Luca Nimmesgern
- & Georg Herink
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Article
| Open AccessTrilobite-inspired neural nanophotonic light-field camera with extreme depth-of-field
Inspired by the optical structure of bifocal compound eyes, the authors demonstrate a nanophotonic light-field camera with large depth of field. By using a spin-multiplexed bifocal metalens array and neural network-based reconstruction, they capture high-resolution images at centimeter to kilometer scale.
- Qingbin Fan
- , Weizhu Xu
- & Ting Xu
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Matters Arising
| Open AccessThe overwhelming role of ballistic photons in ultrasonically guided light through tissue
- Eitan Edrei
- & Giuliano Scarcelli
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Article
| Open AccessAbsolute measurement of cellular activities using photochromic single-fluorophore biosensors and intermittent quantification
Biosensors often report relative rather than absolute values. Here the authors report a method that utilises the photochromic properties of biosensors to provide an absolute measure of the analyte concentration or activity: photochromism-enabled absolute quantification (PEAQ) biosensing.
- Franziska Bierbuesse
- , Anaïs C. Bourges
- & Peter Dedecker
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Matters Arising
| Open AccessReply to: The overwhelming role of ballistic photons in ultrasonically guided light through tissue
- Maysamreza Chamanzar
- , Matteo Giuseppe Scopelliti
- & Michel M. Maharbiz
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Article
| Open AccessUltraviolet optical horn antennas for label-free detection of single proteins
The authors introduce optical horn antennas, a nanophotonic platform combining plasmonic enhancement, efficient collection and background screening, for detection of UV autofluorescence from single proteins. They demonstrate label-free monitoring of protein unfolding and dissociation upon denaturation.
- Aleksandr Barulin
- , Prithu Roy
- & Jérôme Wenger
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Article
| Open Access100 Hz ROCS microscopy correlated with fluorescence reveals cellular dynamics on different spatiotemporal scales
In live-cell microscopy, motion blur limits resolution and contrast. Here the authors use 100 Hz super-resolving Rotating Coherent Scattering (ROCS) microscopy on various dynamic biological systems, and time-window analysis to understand biological effects.
- Felix Jünger
- , Dominic Ruh
- & Alexander Rohrbach
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Article
| Open AccessMeta-programmable analog differentiator
Here, the authors report purposefully perturbed wave chaos that enables analog signal processing with unprecedented fidelity and flexibility.
- Jérôme Sol
- , David R. Smith
- & Philipp del Hougne
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Article
| Open AccessVideo-rate high-precision time-frequency multiplexed 3D coherent ranging
Frequency-modulated continuous wave LiDAR has suffered from limited 3D frame rates. Here, the authors combine a grating for beam steering with a compressed time-frequency analysis for depth retrieval, and demonstrate real-time densely sampled 3D imaging of moving objects with submillimetre localization accuracy.
- Ruobing Qian
- , Kevin C. Zhou
- & Joseph A. Izatt
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Article
| Open AccessHollow-core optical fibre sensors for operando Raman spectroscopy investigation of Li-ion battery liquid electrolytes
New analytical tools are needed to identify chemical degradation and failure mechanisms in Li-ion batteries. Here, the authors report an operando Raman spectroscopy method, based on hollow-core optical fibres, that enables monitoring the chemistry of liquid electrolytes during battery cycling.
- Ermanno Miele
- , Wesley M. Dose
- & Tijmen G. Euser
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Article
| Open AccessDeep-learning two-photon fiberscopy for video-rate brain imaging in freely-behaving mice
The acquisition speed of two-photon fiberscopes is currently suboptimal. Here the authors report advances, including a high-speed scanner and down-sampling scheme as well as a two-stage deep learning (DL) algorithm, to allow high-speed, high-resolution imaging in freely moving mice.
- Honghua Guan
- , Dawei Li
- & Xingde Li
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Article
| Open AccessLongitudinal piezoelectric resonant photoelastic modulator for efficient intensity modulation at megahertz frequencies
Optical intensity modulators are an important component in optics. Here, the authors demonstrate a type of resonant intensity modulator operating in the megahertz frequency regime with record high efficiency and use it for time-of-flight imaging.
- Okan Atalar
- , Raphaël Van Laer
- & Amin Arbabian
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Article
| Open AccessDynamic-quenching of a single-photon avalanche photodetector using an adaptive resistive switch
The limited recovery speed of the single-photon avalanche diodes due to the passive resistor in series strongly reduces the detector’s frequency response. Here Zheng et al., overcome this problem by using an adaptive resistive switch and reaching an avalanche pulse width as small as 30 ns.
- Jiyuan Zheng
- , Xingjun Xue
- & Supratik Guha
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Article
| Open AccessLarge field-of-view non-invasive imaging through scattering layers using fluctuating random illumination
The authors demonstrate non-invasive fluorescence imaging behind scattering layers beyond the optical memory effect. They achieve this by demixing speckle patterns emitted by a fluorescent object under variable unknown random illumination, using matrix factorization and a fingerprint-based reconstruction.
- Lei Zhu
- , Fernando Soldevila
- & Sylvain Gigan
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Article
| Open AccessSilicon-photonics acoustic detector for optoacoustic micro-tomography
High-resolution photoacoustic tomography is challenging due to reduced efficiency of miniaturized piezoelectric elements. Here, the authors fabricate a miniaturized silicon-photonics acoustic detector coated with a sensitivity-enhancing elastomer, and demonstrate high-resolution in vivo imaging.
- Yoav Hazan
- , Ahiad Levi
- & Amir Rosenthal
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Article
| Open AccessAll-fiber high-speed image detection enabled by deep learning
Here, the authors demonstrate high-speed imaging through multimode optical fibers by using the high intermodal dispersion to transform 2D spatial information into 1D temporal pulsed signal streams. Deep learning is used to reconstruct the images of micron-scale objects at high frame rates.
- Zhoutian Liu
- , Lele Wang
- & Qirong Xiao
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Article
| Open AccessTransient quantum beatings of trions in hybrid organic tri-iodine perovskite single crystal
Understanding photo-physics giving rise to quantum beating oscillations in hybrid organic-inorganic perovskites aids their applications in spintronics and quantum information science. Here, authors demonstrate that quantum beatings observed in single crystal perovskite at cryogenic temperatures are originating from positive and negative trions.
- Uyen N. Huynh
- , Ye Liu
- & Z. Valy Vardeny
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Article
| Open AccessExtracting quantitative dielectric properties from pump-probe spectroscopy
Photoinduced changes in transmission, reflection and scattering prevent conventional pump-probe spectroscopy to unambiguously assign the origin of spectral signatures. Ashoka et al. have developed an optical modelling technique to extract quantitative and unambiguous changes in the dielectric function from standard pump-probe measurements.
- Arjun Ashoka
- , Ronnie R. Tamming
- & Akshay Rao
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Article
| Open AccessMeasuring mechanical anisotropy of the cornea with Brillouin microscopy
Here, Brillouin optical microscopy noninvasively visualizes microscale anisotropy of the porcine cornea owing to its lamellar fiber structure and quantifies the longitudinal moduli of the bulk tissue. Anisotropy is also detected in angle-resolved measurement of the human cornea in vivo.
- Amira M. Eltony
- , Peng Shao
- & Seok-Hyun Yun
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Article
| Open AccessAn achromatic X-ray lens
X-ray diffractive and refractive optical elements suffer from chromatic aberrations, limiting high-resolution X-ray microscopes mainly to bright synchrotron sources. Here, the authors experimentally realise an achromatic X-ray lens by combing a focusing diffractive Fresnel zone plate and a defocusing refractive lens.
- Adam Kubec
- , Marie-Christine Zdora
- & Christian David
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Article
| Open AccessDeep tissue localization and sensing using optical microcavity probes
Optical microcavities are useful as probes in cells due to their narrow emission spectra and high sensitivity to environment. Here, the authors use the unique spectral features of microcavities, which are unaffected by tissue scattering, and show 3D localisation and tracking of cells deep in tissues.
- Aljaž Kavčič
- , Maja Garvas
- & Matjaž Humar
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Article
| Open AccessAttosecond photoionisation time delays reveal the anisotropy of the molecular potential in the recoil frame
Photoionization time delays provide insights on the interaction of photon with the electrons. Here the authors explore the role of the molecular potential to the attosecond time delays in the photoionization of CF4 molecule.
- H. Ahmadi
- , E. Plésiat
- & G. Sansone
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Article
| Open AccessKeyhole fluctuation and pore formation mechanisms during laser powder bed fusion additive manufacturing
Understanding the keyhole porosity formation is important in laser powder bed fusion. Here the authors reveal the dynamics of keyhole fluctuation, and collapse that induces bubble formation with three main stages of evolution; growth, shrinkage, and being captured by the solidification front.
- Yuze Huang
- , Tristan G. Fleming
- & Peter D. Lee
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Article
| Open AccessOptical sensors for operando stress monitoring in lithium-based batteries containing solid-state or liquid electrolytes
Chemo-mechanical stress within Li-based batteries detrimentally affects the performance and lifetime of these devices. Here, the authors propose an operando technique using optical fibers embedded in electrodes for internal stress monitoring of cells containing either solid or liquid electrolytes.
- Laura Albero Blanquer
- , Florencia Marchini
- & Jean-Marie Tarascon
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Article
| Open AccessElectro-optic characterization of synthesized infrared-visible light fields
A continuum spanning from 300 and 3000 nm is used to synthesize a single-cycle field transient and measure its waveform through electro-optic sampling, speeding up this sensitive technique so that it can access the electric field of visible light.
- Enrico Ridente
- , Mikhail Mamaikin
- & Nicholas Karpowicz