Featured
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| Open AccessMid-infrared single-pixel imaging at the single-photon level
The authors present an implementation of mid-infrared single-photon computational imaging with a single-element silicon detector. In addition to unique features of single-pixel simplicity and room-temperature operation, the infrared imager offers a superior sensitivity at the single-photon level.
- Yinqi Wang
- , Kun Huang
- & Heping Zeng
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Article
| Open AccessBright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging
Fluorescence imaging in the near-infrared region yields high-quality images that overcome the current depth limitations. Here, the authors report a Tm3 + -based nanoprobe for NIR-IIb/c imaging, providing references to future bioimaging beyond 1700 nm.
- Yulei Chang
- , Haoren Chen
- & Xianggui Kong
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Article
| Open AccessTheoretical and experimental analysis of circularly polarized luminescence spectrophotometers for artifact-free measurements using a single CCD camera
The authors present an artifact-free circularly polarized luminescence spectrophotometer using a single camera and two polarization encoding paths. The spectra are measured in a few seconds without the need of calibration by inverting the role of the paths.
- Bruno Baguenard
- , Amina Bensalah-Ledoux
- & Stéphan Guy
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| Open AccessMid-infrared cross-comb spectroscopy
The authors introduce and demonstrate cross-comb spectroscopy in the mid-infrared as a variant of dual-comb spectroscopy. It provides enhanced performance and allows mid-infrared spectral information to be obtained by near-infrared detection.
- Mingchen Liu
- , Robert M. Gray
- & Alireza Marandi
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Article
| Open AccessMonocular metasurface camera for passive single-shot 4D imaging
The authors present a monocular camera equipped with a single-layer metalens for passive single-shot 4D imaging. It can simultaneously perform high-accuracy depth sensing and highfidelity polarization imaging over an extended depth of field.
- Zicheng Shen
- , Feng Zhao
- & Yuanmu Yang
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| Open AccessIntelligent metasurface system for automatic tracking of moving targets and wireless communications based on computer vision
The authors present an intelligent metasurface system that uses a target detection algorithm combined with a depth camera, to automatically detect the position of moving targets and achieve real-time wireless communications. The system can operate for multiple targets in limited ambient light, outdoor and other realistic environments.
- Weihan Li
- , Qian Ma
- & Tie Jun Cui
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Article
| Open AccessDual-comb optical activity spectroscopy for the analysis of vibrational optical activity induced by external magnetic field
Dual-comb spectroscopy was first applied to the measurement of magnetic optical activity spectroscopy, realizing Doppler-limited gas-phase molecular analysis, and was further extended to the rapid measurement of liquid-phase chiroptical activity.
- Daowang Peng
- , Chenglin Gu
- & Wenxue Li
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Article
| Open AccessVisualizing orthogonal RNAs simultaneously in live mammalian cells by fluorescence lifetime imaging microscopy (FLIM)
No multi-color RNA fluorescent tags are currently available for use in live cells. Here, the authors show that fluorescence lifetime imaging microscopy is advantageous for multiplexed RNA visualization while achieving robust cellular contrast.
- Nadia Sarfraz
- , Emilia Moscoso
- & Esther Braselmann
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Article
| Open AccessRealizing nearly-zero dark current and ultrahigh signal-to-noise ratio perovskite X-ray detector and image array by dark-current-shunting strategy
The high dark current of perovskite photodetectors hinders the full potential of perovskites as active material for X-ray detectors. Here, Jin et al. provide a strategy to reduce the dark current to zero and massively enhance the signal-to-noise ratio of perovskite X-ray detectors and photodetectors.
- Peng Jin
- , Yingjie Tang
- & Yang (Michael) Yang
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Article
| Open AccessDirect digital sensing of protein biomarkers in solution
There are limitations with current protein sensing methods. Here the authors report DigitISA, a digital immunosensor assay based on microchip electrophoretic separation and single-molecule detection that enables quantitation of protein biomarkers in a single, solution-phase step.
- Georg Krainer
- , Kadi L. Saar
- & Tuomas P. J. Knowles
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Article
| Open AccessElement- and enantiomer-selective visualization of molecular motion in real-time
Complex molecules show element- and enantio-specific properties and reactivity. Here the authors demonstrate identification of the element- and enantiomer-selective motion of Ibuprofen molecule using X-ray photons at the carbon K-edge.
- R. Mincigrucci
- , J. R. Rouxel
- & C. Masciovecchio
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Article
| Open AccessIn vivo detection of bile duct pre-cancer with endoscopic light scattering spectroscopy
Diagnosis of bile duct cancer often occur in advanced stages, leading to poor survival. Here, the authors combine light scattering and diffuse reflectance spectroscopies in a minimally invasive endoscopic technique for directly assessing the malignant potential of the bile duct lining, and demonstrate 97% detection accuracy.
- Douglas K. Pleskow
- , Mandeep S. Sawhney
- & Lev T. Perelman
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Article
| Open AccessComputational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin
The authors realize longitudinal deep-brain imaging through an intact mouse skull by constructing a high-speed reflection matrix microscope at 1.3 µm wavelength and developing a computational conjugate adaptive optics algorithm eliminating skull aberrations.
- Yongwoo Kwon
- , Jin Hee Hong
- & Wonshik Choi
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Article
| Open AccessQuantum interference between dark-excitons and zone-edged acoustic phonons in few-layer WS2
Here, the authors investigate the Raman spectra of few-layered WS2 when the excitation energy is in resonance with the dark exciton, and observe a Fano resonance between dark excitonsand zone-edge acoustic phonons.
- Qing-Hai Tan
- , Yun-Mei Li
- & Jun Zhang
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Article
| Open AccessThree-dimensional wide-field fluorescence microscopy for transcranial mapping of cortical microcirculation
A 3D wide-field fluorescence microscopy method is introduced based on optical astigmatism combined with fluorescence source localization. It enables transcranial cortical microcirculation mapping in murine brain with high spatiotemporal resolution.
- Quanyu Zhou
- , Zhenyue Chen
- & Daniel Razansky
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Article
| Open AccessSingle planar photonic chip with tailored angular transmission for multiple-order analog spatial differentiator
The authors present a planar photonic chip, which operate as a multiple-order analog spatial differentiator. It provides a route for designing fast, power-efficient, compact and low-cost devices used in edge detection and optical image processing, thus expanding the functions of standard microscopes.
- Yang Liu
- , Mingchuan Huang
- & Douguo Zhang
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Article
| Open AccessMolecular polariton electroabsorption
The authors investigate whether strong light-matter coupling can alter the nonlinear optical response of molecules inside a microcavity. Focusing on electroabsorption as a model third order nonlinearity, they find that apparent discrepancies between experiment and classical transfer matrix modeling arise from dark states in the system and are not a sign of new physics in the strong coupling regime.
- Chiao-Yu Cheng
- , Nina Krainova
- & Noel C. Giebink
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Article
| Open AccessCompressed ultrahigh-speed single-pixel imaging by swept aggregate patterns
The authors present single-pixel imaging accelerated via swept aggregate patterns (SPI-ASAP), which combines a digital micromirror device with laser scanning for fast and reconfigurable pattern projection, and a lightweight reconstruction algorithm. They demonstrate real-time video streaming at 100 fps, and up to 12,000 fps offline.
- Patrick Kilcullen
- , Tsuneyuki Ozaki
- & Jinyang Liang
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Article
| Open AccessPlasmonic imaging of the layer-dependent electrocatalytic activity of two-dimensional catalysts
Probing the localized electrocatalytic activity of heterogeneous electrocatalysts is crucial. Here, the authors propose a method of imaging the surface charge density and electrocatalytic activity of single two-dimensional electrocatalyst nanosheets.
- Xiaona Zhao
- , Xiao-Li Zhou
- & Xian-Wei Liu
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Article
| Open AccessSingle-shot 3D imaging with point cloud projection based on metadevice
The authors present a single-shot 3D imaging approach utilizing carefully designed point clouds projection based on a metasurface device. They show submillimeter depth accuracy and demonstrate the potential for hand gesture detection.
- Xiaoli Jing
- , Ruizhe Zhao
- & Lingling Huang
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Article
| Open AccessMachine learning assisted interferometric structured illumination microscopy for dynamic biological imaging
Structured Illumination Microscopy allows for the visualization of biological structures at resolutions below the diffraction limit, but this imaging modality is still hampered by high experimental complexity. Here, the authors present a combination of interferometry and machine learning to construct a structured illumination microscope for super resolution imaging of dynamic sub-cellular biological structures in multiple colors.
- Edward N. Ward
- , Lisa Hecker
- & Clemens F. Kaminski
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Article
| Open AccessDetecting and quantifying liquid–liquid phase separation in living cells by model-free calibrated half-bleaching
It is currently debated how to reliably distinguish liquid–liquid phase separation (LLPS) from other mechanisms. Here the authors report model-free calibrated half-FRAP (MOCHA-FRAP) to probe the barrier at the condensate interface that is responsible for preferential internal mixing in LLPS.
- Fernando Muzzopappa
- , Johan Hummert
- & Fabian Erdel
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Article
| Open AccessBond-selective intensity diffraction tomography
The authors introduce Bond-selective Intensity Diffraction Tomography, a computational mid-infrared photothermal microscopy technique based on a standard bright-field microscope and an add-on pulsed light source. It recovers both mid-infrared spectra and bond-selective 3D refractive index maps based on intensity-only measurements.
- Jian Zhao
- , Alex Matlock
- & Ji-Xin Cheng
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Article
| Open AccessFocus image scanning microscopy for sharp and gentle super-resolved microscopy
Super-resolution microscopy techniques can be challenging for live cells and thick samples. Here, the authors propose a method to reduce beam intensity and remove out-of-focus fluorescence background in image-scanning microscopy (ISM) and its combination with stimulated emission depletion (STED).
- Giorgio Tortarolo
- , Alessandro Zunino
- & Giuseppe Vicidomini
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Article
| Open AccessOptical-resolution functional gastrointestinal photoacoustic endoscopy based on optical heterodyne detection of ultrasound
The authors developed an optical-fiber-based photoacoustic endoscope for gastroenterology. It can noninvasively view the internal vascular structures and visualize the hemodynamic response in a lesion.
- Yizhi Liang
- , Wubing Fu
- & Bai-Ou Guan
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Article
| Open AccessThe BrightEyes-TTM as an open-source time-tagging module for democratising single-photon microscopy
The authors developed an open-source, low-cost, multi-channel time-tagging module for fluorescence lifetime image scanning microscopy and correlation spectroscopy that can tag in parallel multiple single-photon events with 30 ps precision.
- Alessandro Rossetta
- , Eli Slenders
- & Giuseppe Vicidomini
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Article
| Open AccessAcousto-holographic reconstruction of whole-cell stiffness maps
Traditional methods for cell stiffness measurements are limited by long processing times and unsuitability for multiple cell analysis. Here, the authors demonstrate a fast technique based on acoustic stimulation and holographic imaging to reconstruct whole-cell stiffness maps of individual and multiple cells.
- Rahmetullah Varol
- , Zeynep Karavelioglu
- & Huseyin Uvet
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Article
| Open AccessDynamic complex opto-magnetic holography
Holography recreates both the amplitude and wave front of a three dimensional object, meaning that the observer perceives the image in the nearly same way as they would the true object. Creating such holographic images is challenging computationally, and requires extremely fast display update. Here, the authors combine a fast memoryless computation algorithm with the ultra-rapid writing based on all-optical switching of a ferrimagnetic film.
- M. Makowski
- , J. Bomba
- & A. Stupakiewicz
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Article
| Open AccessRemote near-field spectroscopy of vibrational strong coupling between organic molecules and phononic nanoresonators
Vibrational strong coupling (VSC) promises ultrasensitive IR spectroscopy and modification of material properties. Here, nanoscale mapping of VSC between organic molecules and individual IR nanoresonators is achieved by remote near-field spectroscopy.
- Irene Dolado
- , Carlos Maciel-Escudero
- & Rainer Hillenbrand
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Article
| Open AccessUltrasensitive probing of plasmonic hot electron occupancies
Experimental evidence is given that upon the optical excitation of surface plasmon polaritons, a nonthermal electron population appears in the topmost domain of the plasmonic film directly coupled to the local fields.
- Judit Budai
- , Zsuzsanna Pápa
- & Péter Dombi
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Article
| Open AccessDemonstration of intracellular real-time molecular quantification via FRET-enhanced optical microcavity
The authors introduce an active-mode optical microcavity sensor with enhanced sensitivity via Förster resonant energy transfer. Changes in lasing wavelengths of both donor and acceptor enable quantitative molecular analysis and real-time monitoring of intracellular molecules.
- Yaping Wang
- , Marion C. Lang
- & Pu Wang
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Article
| Open AccessSuper-resolution microscopy enabled by high-efficiency surface-migration emission depletion
The authors report high-efficiency emission depletion through a surface migration emission depletion mechanism, which takes advantage of the effects of surface quenching and energy migration in nanocrystals. They demonstrate super-resolution microscopy with very low depletion saturation intensities.
- Rui Pu
- , Qiuqiang Zhan
- & Xiaogang Liu
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Article
| Open AccessHyperbolic material enhanced scattering nanoscopy for label-free super-resolution imaging
The authors demonstrate a label-free superresolution imaging method by using a hyperbolic material as a substrate for tailored light-matter interactions. The hyperbolic material enhanced scattering, combined with dark-field detection, result in 5.5-fold resolution improvement beyond the diffraction limit.
- Yeon Ui Lee
- , Shilong Li
- & Zhaowei Liu
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Article
| Open AccessNanoscale heterogeneity of ultrafast many-body carrier dynamics in triple cation perovskites
The optoelectronic performance of lead halide perovskite in highfluence applications are hindered by heterogeneous multi-polaron interactions in the nanoscale. Here, Nishda et al. spatially resolve sub-ns relaxation dynamics on the nanometer scale by ultrafast infrared pumpprobe nanoimaging.
- Jun Nishida
- , Peter T. S. Chang
- & Markus B. Raschke
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Article
| Open AccessHigh-speed, scanned laser structuring of multi-layered eco/bioresorbable materials for advanced electronic systems
Designing and manufacturing eco/bioresorbable electronic systems remains a challenge. The authors introduce a picosecond-pulsed laser-based scheme that exploits controlled patterning, thinning, and/or cutting to manipulate multilayers of eco/bioresorbable materials for a wide range of advanced electronic systems.
- Quansan Yang
- , Ziying Hu
- & John A. Rogers
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Article
| Open AccessFlexible hyperspectral surface plasmon resonance microscopy
The authors developed a pristine hyperspectral SPR microscopy that enables monochromatic and polychromatic SPR imaging with flexible field-of-view option, single-pixel spectral SPR sensing and 2D quantification of thin films with resonant wavelength images.
- Ziwei Liu
- , Jingning Wu
- & Zhi-mei Qi
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Article
| Open AccessReal-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography
Fiber-based micro-endoscopes are minimally invasive, but 3D imaging is limited by the need for bulky optical elements or rigid fibers. Here, the authors demonstrate holographic imaging through flexible and dynamically bent multi-core fibers by adding partially reflecting mirror to the distal fiber-tip.
- Noam Badt
- & Ori Katz
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Article
| Open AccessSub-optical-cycle light-matter energy transfer in molecular vibrational spectroscopy
Energy transfer between the electromagnetic field and atoms or molecules is fundamentally interesting. Here the authors demonstrate stepwise energy transfer between broadband mid-infrared optical pulses and vibrating methylsulfonylmethane molecules in aqueous solution.
- Martin T. Peschel
- , Maximilian Högner
- & Ioachim Pupeza
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Article
| Open AccessSub-wavelength patterned pulse laser lithography for efficient fabrication of large-area metasurfaces
Fabrication of metasurfaces with nanoscale structures is inefficient for large areas. Here, the authors introduce patterned pulse laser lithography for creating structured arrays with sub-wavelength feature on large-area thin films under ambient conditions.
- Lingyu Huang
- , Kang Xu
- & Shaolin Xu
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Article
| Open AccessTracking moving objects through scattering media via speckle correlations
Imaging though strongly scattering media is challenging and computationally intensive. Here, the authors show that tracking of moving objects can be achieved with minimal computational effort by combining cross-correlations of the measured speckle pattern at different times.
- Y. Jauregui-Sánchez
- , H. Penketh
- & J. Bertolotti
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Article
| Open AccessMetasurface-enhanced light detection and ranging technology
Mimicking human vision with metasurfaces, the authors propose a new paradigm for high field of view and ultrafast LiDAR, achieving performances also relevant for the next generation of imaging system for ADAS and robotic systems.
- Renato Juliano Martins
- , Emil Marinov
- & Patrice Genevet
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Article
| Open AccessQuantum and non-local effects offer over 40 dB noise resilience advantage towards quantum lidar
Sensitivity to noise is currently an obstacle to the use of quantum imaging techniques in real-world scenarios. Here, exploiting non-local cancellation of dispersion on time-frequency entangled photons, the authors show a 43dB improvement in resilience to noise for imaging protocols towards a quantum LiDAR.
- Phillip S. Blakey
- , Han Liu
- & Amr S. Helmy
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Article
| Open AccessMiniature optoelectronic compound eye camera
The defocusing problem has been considered the main bottleneck for developing optoelectronic μ-compound eye (CE) cameras. Here, the authors report miniature optoelectronic CE cameras with an ommatidia logarithmic-profile. The camera enables large field-of-view imaging, spatial position identification, and sensitive trajectory monitoring of moving targets.
- Zhi-Yong Hu
- , Yong-Lai Zhang
- & Hong-Bo Sun
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Article
| Open AccessBattery-free wireless imaging of underwater environments
The authors present an approach to underwater imaging, which does not require tethering or batteries. The low-power camera uses power from harvested acoustic energy and communicates colour images wirelessly via acoustic backscatter.
- Sayed Saad Afzal
- , Waleed Akbar
- & Fadel Adib
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Article
| Open AccessOptical quantum super-resolution imaging and hypothesis testing
Estimating the angular separation between two incoherent sources below the diffraction limit is challenging. Hypothesis testing and quantum state discrimination techniques are used to super-resolve sources of different brightness with a simple optical interferometer.
- Ugo Zanforlin
- , Cosmo Lupo
- & Zixin Huang
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Article
| Open AccessHigh-fluence and high-gain multilayer focusing optics to enhance spatial resolution in femtosecond X-ray laser imaging
Here, the authors realize an ultra-high fluence X-ray laser by high-gain multilayer focusing optics. This enables in-solution imaging with 2-nm resolution in a single-pulse exposure, making strides toward biomolecular imaging under physiological conditions.
- Hirokatsu Yumoto
- , Takahisa Koyama
- & Haruhiko Ohashi
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Article
| Open AccessLife at high temperature observed in vitro upon laser heating of gold nanoparticles
Studying microorganisms at high temperatures is challenging on conventional optical microscopes. Here, the authors introduce the concept of microscale laser heating over the full field of view by using gold nanoparticles as light absorbers, and study thermophile species up to 80 °C.
- Céline Molinaro
- , Maëlle Bénéfice
- & Guillaume Baffou
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Article
| Open AccessThe primeval optical evolving matter by optical binding inside and outside the photon beam
Optical binding enables light-induced assembly of many particles within a focus area. Here, the authors demonstrate that optical binding can occur outside the irradiated area by scattered light interacting with the particles outside the focus, generating arc-shape potential wells for particle trapping.
- Chih-Hao Huang
- , Boris Louis
- & Hiroshi Masuhara
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Article
| Open AccessUltrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics
The authors introduce differentially enhanced compressed ultrafast photography, a phase imaging platform that combines high speed and sensitivity. They visualise propagation of passive current flows along myelinated axons, and electromagnetic pulses in lithium niobate.
- Yide Zhang
- , Binglin Shen
- & Lihong V. Wang