A nanoscopic force clamp enables high-throughput single-molecule analysis of DNA under tension without connection to a macroscopic instrument.
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References
Nickels, P.C. et al. Molecular force spectroscopy with a DNA origami-based nanoscopic force clamp. Science 354, 305–307 (2016).
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Doerr, A. Single-molecule force analysis, unplugged. Nat Methods 13, 970–971 (2016). https://doi.org/10.1038/nmeth.4094
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DOI: https://doi.org/10.1038/nmeth.4094